The 8;21 translocation in leukemogenesis (Q35779709)

10 August 2017

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title

The 8;21 translocation in leukemogenesis (English)

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10 August 2017

Luke F Peterson

1

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PubMed ID

15156181

10 August 2017

Dong-Er Zhang

series ordinal

2

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PubMed ID

15156181

10 August 2017

language of work or name

English

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publication date

1 May 2004

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10 August 2017

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10 August 2017

23

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10 August 2017

24

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10 August 2017

4255-4262

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207727

10 August 2017

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cites work

Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Nuclear matrix, dynamic histone acetylation and transcriptionally active chromatin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Organization of chromatin in cancer cells: role of signalling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

ETO-2, a new member of the ETO-family of nuclear proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Secondary leukemias induced by topoisomerase-targeted drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Isolation of a yeast artificial chromosome spanning the 8;21 translocation breakpoint t(8;21)(q22;q22.3) in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Multiple regions of ETO cooperate in transcriptional repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The AML1/ETO fusion protein activates transcription of BCL-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor α Regulation of ELA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Bcl11a is essential for normal lymphoid development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Potential involvement of the AML1-MTG8 fusion protein in the granulocytic maturation characteristic of the t(8;21) acute myelogenous leukemia revealed by microarray analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

t(8;21) breakpoints are clustered between alternatively spliced exons of MTG8

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Structure and expression of the human MTG8/ETO gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Cooperative binding of Ets-1 and core binding factor to DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Molecular characterization of genomic AML1-ETO fusions in childhood leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Oligomerization of ETO is obligatory for corepressor interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207727

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207727

1 reference

10 August 2017

1 reference

PubMed ID

15156181