TGF-beta inhibitors for the treatment of cancer (Q36187040)

12 August 2017

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title

TGF-beta inhibitors for the treatment of cancer (English)

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12 August 2017

Michael Lahn

1

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12 August 2017

Susanne Kloeker

series ordinal

2

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12 August 2017

Brandi S Berry

series ordinal

3

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12 August 2017

language of work or name

English

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publication date

1 June 2005

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Expert Opinion on Investigational Drugs

12 August 2017

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12 August 2017

14

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12 August 2017

6

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12 August 2017

629-643

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Isolation from murine sarcoma cells of novel transforming growth factors potentiated by EGF

12 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Autocrine growth factors and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Role of transforming growth factor-beta signaling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

TGF-beta signaling in mammary gland development and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

TGFbeta signaling in growth control, cancer, and heritable disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Stromal fibroblasts in cancer initiation and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

TGF-beta signaling in tumor suppression and cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Role of myofibroblasts in tumour encapsulation of hepatocellular carcinoma in haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

A multigenic program mediating breast cancer metastasis to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Genetic polymorphisms in the TGF-beta 1 gene and breast cancer survival: a report from the Shanghai Breast Cancer Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Determinants of specificity in TGF-beta signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Antisense therapy in oncology: new hope for an old idea?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Future options with trastuzumab for primary systemic and adjuvant therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Monoclonal antibodies in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Etanercept: a clinical review of current and emerging indications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Development of TGF-beta signalling inhibitors for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Lateral signaling enhances TGF-beta response complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

The addition of interleukin-6 soluble receptor and transforming growth factor beta1 improves a preoperative nomogram for predicting biochemical progression in patients with clinically localized prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Transforming growth factor-beta 1 in reproduction and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

TGF-beta influences the life and death decisions of T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

The liver in transforming growth factor-Beta-1 (TGF-beta 1) null mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Smad2 role in mesoderm formation, left-right patterning and craniofacial development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

The Smads: transcriptional regulation and mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Smad3 mutant mice develop metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Mutation analysis of the Smad3 gene in human osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.6.629

10.1517/13543784.14.6.629

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference