Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition (Q36187316)

12 August 2017

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition (English)

1 reference

12 August 2017

4

Alan R Fersht

1 reference

12 August 2017

Rainer Wilcken

1

1 reference

12 August 2017

GuoZhen Wang

series ordinal

2

1 reference

12 August 2017

Frank M Boeckler

series ordinal

3

1 reference

12 August 2017

language of work or name

English

0 references

publication date

6 August 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

12 August 2017

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12 August 2017

109

1 reference

12 August 2017

34

1 reference

12 August 2017

13584-13589

1 reference

First-order rate-determining aggregation mechanism of p53 and its implications

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Awakening guardian angels: drugging the p53 pathway

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Protein aggregation processes: In search of the mechanism

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Heat-induced denaturation and aggregation of ovalbumin at neutral pH described by irreversible first-order kinetics

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Rescuing the function of mutant p53.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Thermodynamic stability of wild-type and mutant p53 core domain

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Oligomerization of oncoprotein p53.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

The conformation and the aggregation kinetics of α-synuclein depend on the proline residues in its C-terminal region

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Protein aggregation kinetics during Protein A chromatography. Case study for an Fc fusion protein

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Fibrillar aggregates of the tumor suppressor p53 core domain

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Correlation of metabolic stability and altered quaternary structure of oncoprotein p53 with cell transformation

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3427094

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

23 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1211550109

Kinetic Instability of p53 Core Domain Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1211550109

SV40 T antigen binds specifically to a cellular 53 K protein in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1211550109

Kinetics of Different Processes in Human Insulin Amyloid Formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1211550109

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22869713

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aggregation of recombinant human interferon gamma: kinetics and structural transitions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22869713

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1211550109

1 reference

12 August 2017

0 references

1 reference

12 August 2017

1 reference