Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells. (Q36191432)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245196%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells (English)

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20 January 2020

2

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20 January 2020

Jérôme Kucharczak

3

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20 January 2020

Jesús Salgado

8

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20 January 2020

Jean-Luc Coll

9

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20 January 2020

author name string

Juan Garcia Valero

1

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20 January 2020

Yannis Guillemin

4

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20 January 2020

Diana Gimenez

5

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20 January 2020

Julien Prudent

6

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20 January 2020

Germain Gillet

7

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20 January 2020

Abdel Aouacheria

10

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20 January 2020

language of work or name

English

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publication date

18 January 2011

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20 January 2020

published in

Journal of Cell Science

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20 January 2020

volume

124

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20 January 2020

issue

Pt 4

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20 January 2020

page(s)

556-564

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Active fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergence

20 January 2020

cites work

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Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process

1 October 2017

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1 October 2017

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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

1 October 2017

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Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores.

1 October 2017

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Bcl-XL inhibits membrane permeabilization by competing with Bax.

1 October 2017

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1 October 2017

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1 October 2017

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A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

1 October 2017

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1 October 2017

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The Bcl-2 apoptotic switch in cancer development and therapy

1 October 2017

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TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.

1 October 2017

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Noninvasive optical imaging of ovarian metastases using Cy5-labeled RAFT-c(-RGDfK-)4.

1 October 2017

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Therapeutic peptides: Targeting the mitochondrion to modulate apoptosis

1 October 2017

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Antibacterial peptides for therapeutic use: obstacles and realistic outlook

1 October 2017

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Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells

1 October 2017

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Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment

1 October 2017

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Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide.

1 October 2017

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Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

1 October 2017

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 October 2017

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1 October 2017

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1 October 2017

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Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins

1 October 2017

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Conformational control of Bax localization and apoptotic activity by Pro168.

1 October 2017

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1 October 2017

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.

1 October 2017

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2 July 2018

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2 July 2018

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2 July 2018

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Synthesis and biological characterisation of targeted pro-apoptotic peptide.

2 July 2018

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A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity.

22 September 2018

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Distinct domains control the addressing and the insertion of Bax into mitochondria.

22 September 2018

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Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

22 September 2018

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The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium.

22 September 2018

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MCF-7 breast cancer cells grown as multicellular spheroids in vitro: effect of 17 beta-estradiol.

22 September 2018

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Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores

22 September 2018

1 reference

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A proapoptotic peptide for the treatment of solid tumors

5 December 2018

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12 December 2020

Bax expression decreases significantly from primary tumor to metastasis in colorectal cancer

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12 December 2020

Membrane-insertion fragments of Bcl-xL, Bax, and Bid

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12 December 2020

A human tumor lung metastasis model in athymic nude rats

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12 December 2020

Thrombin stimulates melanoma tumor-cell binding to endothelial cells and subendothelial matrix

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Targeted delivery of activatable fluorescent pro-apoptotic peptide into live cells

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12 December 2020

Identifiers

DOI

10.1242/JCS.076745

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245196%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

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20 January 2020

PubMed publication ID

21245196

1 reference