Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy (Q36205383)

12 August 2017

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title

Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy (English)

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12 August 2017

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Harry P de Koning

1

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author name string

Daniel J Bridges

series ordinal

2

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PubMed ID

16040150

12 August 2017

Richard J S Burchmore

series ordinal

3

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12 August 2017

1 July 2005

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FEMS Microbiology Reviews

12 August 2017

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12 August 2017

29

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12 August 2017

5

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12 August 2017

987-1020

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Purine Uptake and Utilization by the Avian Malaria Parasite Plasmodium lophurae*

12 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Purine and pyrimidine metabolism in the Trypanosomatidae

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Identification and characterisation of high affinity nucleoside and nucleobase transporters in Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Nucleoside uptake in Trypanosoma cruzi: analysis of a mutant resistant to tubercidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A highly selective, high-affinity transporter for uracil in Trypanosoma brucei brucei: evidence for proton-dependent transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Nucleoside transporters of parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Arsenical-resistant trypanosomes lack an unusual adenosine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Functional expression and characterization of a purine nucleobase transporter gene from Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A Leishmania major nucleobase transporter responsible for allopurinol uptake is a functional homolog of the Trypanosoma brucei H2 transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Purine base transport in wild-type and mycophenolic acid-resistant Tritrichomonas foetus

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Cloning and functional expression of a gene encoding a P1 type nucleoside transporter from Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A nucleoside transporter from Trypanosoma brucei involved in drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Isolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Molecular and functional characterization of the first nucleobase transporter gene from African trypanosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Trypanocidal activity of melamine-based nitroheterocycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Identification of the first pyrimidine nucleobase transporter in Leishmania: similarities with the Trypanosoma brucei U1 transporter and antileishmanial activity of uracil analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Modern chemotherapeutic options for malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Toxoplasma gondii: transmission, diagnosis and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Treatment of cutaneous leishmaniasis with a combination of allopurinol and low-dose meglumine antimoniate

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Transporters in African trypanosomes: role in drug action and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Changes in properties of adenosine transporters in Trypanosoma evansi and modes of selection of resistance to the melaminophenyl arsenical drug, Mel Cy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Changes in adenosine transport associated with melaminophenyl arsenical (Mel CY) resistance in Trypanosoma evansi: down-regulation and affinity changes of the P2 transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Alteration to one of three adenosine transporters is associated with resistance to cymelarsan in Trypanosoma evansi

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Equilibrative nucleoside transporter family members from Leishmania donovani are electrogenic proton symporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Treatment of human African trypanosomiasis--present situation and needs for research and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Stimulated transport of adenosine, guanosine and hypoxanthine in Crithidia luciliae: metabolic machinery in which the parasite has a distinct advantage over the host.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Sinefungin shares AdoMet-uptake system to enter Leishmania donovani promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Genetic Analysis of Nucleoside Transport in Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Leishmania donovani: characteristics of adenosine and inosine transporters in promastigotes of two different strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Substrate depletion upregulates uptake of myo-inositol, glucose and adenosine in Leishmania.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Kinetics and stoichiometry of a proton/myo-inositol cotransporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

The equilibrative nucleoside transporter family, SLC29

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

The concentrative nucleoside transporter family, SLC28

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Nucleobase transporters (review).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Characterisation of a concentrative type of adenosine transporter from Arabidopsis thaliana (ENT1,At).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Functional characterization of a H+/nucleoside co-transporter (CaCNT) from Candida albicans, a fungal member of the concentrative nucleoside transporter (CNT) family of membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Nucleoside and nucleobase transporters in parasitic protozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Identification and characterization of purine nucleoside transporters from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Purine and Pyrimidine Synthesis by the Avian Malaria Parasite, Plasmodium lophurae*

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Synthesis of adenosine nucleotides from hypoxanthine by human malaria parasites (Plasmodium Falciparum) in continuous erythrocyte culture: inhibition by hadacidin but not alanosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

In vitro inhibition of Plasmodium falciparum by pyrazofurin, an inhibitor of pyrimidine biosynthesis de novo

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Inhibition of pyrimidine biosynthesis de novo in Plasmodium falciparum by 2-(4-t-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Nucleoside and nucleobase transport in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Parasite-induced permeation of nucleosides in Plasmodium falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Pore size of the malaria parasite's nutrient channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Xanthine oxidase inhibits growth of Plasmodium falciparum in human erythrocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Expression of substrate-specific transporters encoded by Plasmodium falciparum in Xenopus laevis oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Localization of the Plasmodium falciparum PfNT1 nucleoside transporter to the parasite plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Biochemical and molecular characterization of nucleoside triphosphate hydrolase isozymes from the parasitic protozoan Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Uptake of Nitrobenzylthioinosine and Purine β- l -Nucleosides by Intracellular Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A low-affinity nucleobase transporter in the protozoan parasite Giardia intestinalis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Purine salvage networks in Giardia lamblia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

The purine nucleoside phosphorylase from Trichomonas vaginalis is a homologue of the bacterial enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A novel mechanism of mycophenolic acid resistance in the protozoan parasite Tritrichomonas foetus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Molecular biology studies of tubercidin resistance in Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Defective transport of pyrazolopyrimidine ribosides in insensitive Trypanosoma cruzi wild strains is a parasite-stage specific and reversible characteristic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the regression and prevention of electrocardiographic abnormalities during 9 years of follow-up

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Antitrypanosomal Effect of Allopurinol: Conversion in Vivo to Aminopyrazolopyrimidine Nucleotides by Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Uptake of pentamidine in Trypanosoma brucei brucei is mediated by the P2 adenosine transporter and at least one novel, unrelated transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Further characterization of an adenosine transport system in the mitochondrial fraction of rat testis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Subcellular localisation of purine-metabolising enzymes in Leishmania mexicana mexicana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Point mutations in a nucleoside transporter gene from Leishmania donovani confer drug resistance and alter substrate selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Functional analysis of an inosine-guanosine transporter from Leishmania donovani. The role of conserved residues, aspartate 389 and arginine 393.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Differential targeting of two glucose transporters from Leishmania enriettii is mediated by an NH2-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Sequences required for the flagellar targeting of an integral membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Mammalian ABC transporters in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

ABC transporters and the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Desciclovir permeation of the human erythrocyte membrane by nonfacilitated diffusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Membrane permeation characteristics of abacavir in human erythrocytes and human T-lymphoblastoid CD4+ CEM cells: comparison with (-)-carbovir

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

New (1-deaza)purine derivatives via efficient C-2 nitration of the (1-deaza)purine ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Drug transport and drug resistance in African trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A drug resistance determinant in Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Chemotherapy of canine leishmaniosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Trypanosoma brucei: expression of multiple purine transporters prevents the development of allopurinol resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Overexpression of LaMDR2, a novel multidrug resistance ATP-binding cassette transporter, causes 5-fluorouracil resistance in Leishmania amazonensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Selective transport of a new class of purine antimetabolites by the protozoan parasite Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Potential chemotherapeutic targets in the purine metabolism of parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Compartmentation of carbohydrate metabolism in trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)-nucleoside transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Nucleoside permeation in mouse erythrocytes infected with Plasmodium yoelii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Antimalarial action of nitrobenzylthioinosine in combination with purine nucleoside antimetabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Adenosine analogues as antimetabolites against Plasmodium falciparum malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

L-purine nucleosides as selective antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

New malaria chemotherapy developed by utilization of a unique parasite transport system

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a search for reversal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

ABC proteins of Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

ABC transporters and drug resistance in parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Multidrug resistance in the protozoan parasite Entamoeba histolytica

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

P-glycoprotein inhibitors modulate accumulation and efflux of xenobiotics in extra and intracellular Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Definitive proof for a role of pfmdr 1 in quinoline resistance in Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Identification of a transcription factor like protein at the TOR locus in Leishmania mexicana amazonensis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Reduced purine accumulation is encoded on an amplified DNA in Leishmania mexicana amazonensis resistant to toxic nucleosides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Chimeric constructs between human and rat equilibrative nucleoside transporters (hENT1 and rENT1) reveal hENT1 structural domains interacting with coronary vasoactive drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Transmembrane domain 5 of the LdNT1.1 nucleoside transporter is an amphipathic helix that forms part of the nucleoside translocation pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

The GxxxG motif: a framework for transmembrane helix-helix association

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Cylindrical channels from concave helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Uridine recognition motifs of human equilibrative nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

DIALIGN 2: improvement of the segment-to-segment approach to multiple sequence alignment

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Inferring phylogenies from protein sequences by parsimony, distance, and likelihood methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Purine nucleobase transport in bloodstream forms of Trypanosoma brucei brucei is mediated by two novel transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Characterization of a Nucleoside/Proton Symporter in ProcyclicTrypanosoma brucei brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

Differential regulation of nucleoside and nucleobase transporters in Crithidia fasciculata and Trypanosoma brucei brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

A nutrient-permeable channel on the intraerythrocytic malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEMSRE.2005.03.004

10.1016/J.FEMSRE.2005.03.004

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

16040150