Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation. (Q36216084)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

0 references

1 reference

Jobin Varkey

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Balachandra G Hegde

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Naiqian Cheng

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Ralf Langen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Alasdair C Steven

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

language of work or name

English

0 references

publication date

5 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

7 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

287

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

issue

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

page(s)

29301-29311

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein

7 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

A soluble α-synuclein construct forms a dynamic tetramer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Neuropathology in mice expressing mouse alpha-synuclein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Alpha-synuclein populates both elongated and broken helix states on small unilamellar vesicles

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

α-Synuclein-induced tubule formation in lipid bilayers

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Multiple modes of endophilin-mediated conversion of lipid vesicles into coated tubes: implications for synaptic endocytosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Alpha-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Intermediate structures in the cholate-phosphatidylcholine vesicle-micelle transition

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Examining the contributions of lipid shape and headgroup charge on bilayer behavior

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Investigation of alpha-synuclein fibril structure by site-directed spin labeling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Structure and dynamics of micelle-bound human alpha-synuclein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

alpha-Synuclein locus triplication causes Parkinson's disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

A broken alpha -helix in folded alpha -Synuclein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Curvature of clathrin-coated pits driven by epsin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Generation of high curvature membranes mediated by direct endophilin bilayer interactions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

A Drosophila model of Parkinson's disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Alpha-synuclein in Lewy bodies

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: application to spin-labeled mutants of bacteriorhodopsin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Vesicle-micelle transition of phosphatidylcholine and octyl glucoside elucidated by cryo-transmission electron microscopy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Amphipathic helix motif: classes and properties

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

3-D Structures of Macromolecules Using Single-Particle Analysis in EMAN

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Cell and tissue distribution and developmental change of neuron specific 14 kDa protein (phosphoneuroprotein 14).

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Amphipathic helixes and plasma lipoproteins: thermodynamic and geometric considerations

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

29 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Spin-label EPR on alpha-synuclein reveals differences in the membrane binding affinity of the two antiparallel helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Broken helix in vesicle and micelle-bound alpha-synuclein: insights from site-directed spin labeling-EPR experiments and MD simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

The determination of pair distance distributions by pulsed ESR using Tikhonov regularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Recent advances in site-directed spin labeling of proteins

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436199

21 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.365817

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

21 January 2018

1 reference

12 December 2020

Antiparallel arrangement of the helices of vesicle-bound alpha-synuclein

1 reference

12 December 2020

A stable lipid-induced aggregate of alpha-synuclein

1 reference

12 December 2020

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

1 reference

12 December 2020

Direct evidence of coexisting horseshoe and extended helix conformations of membrane-bound alpha-synuclein

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M112.365817

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22767608%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

22767608

1 reference