Heparan sulphate proteoglycans: the sweet side of development (Q36216124)

12 August 2017

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title

Heparan sulphate proteoglycans: the sweet side of development (English)

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12 August 2017

Norbert Perrimon

3

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author name string

Udo Häcker

series ordinal

1

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PubMed ID

16072037

12 August 2017

Kent Nybakken

series ordinal

2

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12 August 2017

1 July 2005

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Nature Reviews Molecular Cell Biology

12 August 2017

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12 August 2017

6

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12 August 2017

530-541

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12 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrm1681

12 August 2017

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cites work

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Wnts as morphogens? The view from the wing of Drosophila

21 January 2018

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Morphogens, their identification and regulation

21 January 2018

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Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila

21 January 2018

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Genetic dissection of proteoglycan function in Drosophila and C. elegans

21 January 2018

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Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

21 January 2018

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The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

21 January 2018

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The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila.

21 January 2018

1 reference

Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process.

21 January 2018

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Dally regulates Dpp morphogen gradient formation in the Drosophila wing.

21 January 2018

1 reference

Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans.

21 January 2018

1 reference

Order out of chaos: assembly of ligand binding sites in heparan sulfate

21 January 2018

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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

21 January 2018

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Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos

21 January 2018

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Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.

21 January 2018

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The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension

21 January 2018

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Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer).

21 January 2018

1 reference

Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans

21 January 2018

1 reference

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

21 January 2018

1 reference

UDP-sugar transporter implicated in glycosylation and processing of Notch

21 January 2018

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Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events

21 January 2018

1 reference

Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila

21 January 2018

1 reference

Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog

21 January 2018

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The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog

21 January 2018

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Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.

21 January 2018

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Do morphogen gradients arise by diffusion?

21 January 2018

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Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation

21 January 2018

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Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

21 January 2018

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Spatial regulation of Wingless morphogen distribution and signaling by Dally-like protein

21 January 2018

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Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity

21 January 2018

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Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

21 January 2018

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Dally-like protein, a new Drosophila glypican with expression overlapping with wingless.

21 January 2018

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Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

21 January 2018

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Wingless, hedgehog and heparan sulfate proteoglycans.

21 January 2018

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Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways

21 January 2018

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Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate

21 January 2018

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Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan

21 January 2018

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Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.

21 January 2018

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Fringe is a glycosyltransferase that modifies Notch

21 January 2018

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Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain

21 January 2018

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Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein

21 January 2018

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Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance.

21 January 2018

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Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division.

21 January 2018

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Perlecan participates in proliferation activation of quiescent Drosophila neuroblasts.

21 January 2018

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Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

21 January 2018

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Diversity does make a difference: fibroblast growth factor-heparin interactions

21 January 2018

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Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction

21 January 2018

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Drosophila heparan sulfate 6-O-sulfotransferase (dHS6ST) gene. Structure, expression, and function in the formation of the tracheal system.

21 January 2018

1 reference

EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans

21 January 2018

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sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination

21 January 2018

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Differential sulfations and epimerization define heparan sulfate specificity in nervous system development.

21 January 2018

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The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors.

21 January 2018

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HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient

21 January 2018

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Oligosaccharide microarrays to decipher the glyco code

21 January 2018

1 reference

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

21 January 2018

1 reference

Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)

21 January 2018

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The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes

21 January 2018

1 reference

Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning and identification of mutations.

21 January 2018

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Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

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The ins and outs of Wingless signaling.

21 January 2018

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Regulation of Hedgehog signaling: a complex story

21 January 2018

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TGF-beta family signal transduction in Drosophila development: from Mad to Smads.

21 January 2018

1 reference

sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis

21 January 2018

1 reference

The Caenorhabditis elegans sqv genes and functions of proteoglycans in development

21 January 2018

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Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis

21 January 2018

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Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans

21 January 2018

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Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity

21 January 2018

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Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ

21 January 2018

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Wnt signaling: a common theme in animal development

21 January 2018

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Developmental roles of heparan sulfate proteoglycans in Drosophila

31 March 2020

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Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation

31 March 2020

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The loss of glypican-3 induces alterations in Wnt signaling

31 March 2020

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Wingless gradient formation in the Drosophila wing

31 March 2020

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Glypicans shunt the Wingless signal between local signalling and further transport.

31 March 2020

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Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling

31 March 2020

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Heparin structure and interactions with basic fibroblast growth factor

31 March 2020

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Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase

31 March 2020

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The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1681

1 reference

PubMed ID

16072037

Dimensions Publication ID

12 August 2017

0 references

1 reference

PubMed ID

16072037