Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges (Q36219699)

12 August 2017

1 reference

title

Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges (English)

1 reference

12 August 2017

cardiovascular disease

1 reference

Erding Hu

1

1 reference

PubMed ID

16083339

12 August 2017

Dennis Lee

series ordinal

2

1 reference

PubMed ID

16083339

12 August 2017

language of work or name

English

0 references

publication date

1 August 2005

1 reference

Expert Opinion on Therapeutic Targets

12 August 2017

1 reference

12 August 2017

9

1 reference

12 August 2017

4

1 reference

12 August 2017

715-736

1 reference

Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

12 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Atherosclerosis — An Inflammatory Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

The GTP-binding protein Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho-family GTPases in cadherin-mediated cell-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rocks: multifunctional kinases in cell behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

RHO SIGNALING in vascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

RhoE binds to ROCK I and inhibits downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Protein kinase C: structure, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

The Rho-associated protein kinase p160ROCK is required for centrosome positioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

New roads leading to Ca2+ sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Divergent effects of estrogen and nicotine on Rho-kinase expression in human coronary vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Myosin light chain phosphatase: subunit composition, interactions and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Disturbance of endothelial barrier function by bacterial toxins and atherogenic mediators: a role for Rho/Rho kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

HMG CoA reductase inhibitor suppresses the expression of tissue factor and plasminogen activator inhibitor-1 induced by angiotensin II in cultured rat aortic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

RhoA is required for monocyte tail retraction during transendothelial migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

RhoA and ROCK promote migration by limiting membrane protrusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho kinase is required for CCR7‐mediated polarization and chemotaxis of T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Thrombin-induced activation of RhoA in platelet shape change.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Comparison of inhibitory effects of Y-27632, a Rho kinase inhibitor, in strips of small and large mesenteric arteries from spontaneously hypertensive and normotensive Wistar-Kyoto rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

RhoA expression is controlled by nitric oxide through cGMP-dependent protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Inhibition of Rho-kinase stimulates nitric oxide-independent vasorelaxation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Enhancement of Rho/Rho-kinase system in regulation of vascular smooth muscle contraction in tachycardia-induced heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Long-Term Inhibition of Rho-Kinase Suppresses Neointimal Formation After Stent Implantation in Porcine Coronary Arteries: Involvement of Multiple Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Stent implantation activates RhoA in human arteries: inhibitory effect of rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Beyond lipid lowering: the role of statins in vascular protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Endothelium-dependent effects of statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Antiischemic properties of fasudil in experimental models of vasospastic angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

RhoA-mediated Ca2+ sensitization in erectile function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Phosphodiesterase-5 inhibition synergizes rho-kinase antagonism and enhances erectile response in male hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho-associated kinase phosphorylates MARCKS in human neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Collapsin response mediator protein switches RhoA and Rac1 morphology in N1E-115 neuroblastoma cells and is regulated by Rho kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.715

21 January 2018

Identifiers

DOI

10.1517/14728222.9.4.715

1 reference

12 August 2017

1 reference

PubMed ID

16083339