Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation (Q36219998)

12 August 2017

Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation (English)

1 reference

12 August 2017

8

Valerie Daggett

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12 August 2017

Dan Wang

1

1 reference

12 August 2017

Ian M Robertson

2

1 reference

12 August 2017

Monica X Li

3

1 reference

12 August 2017

Michelle E McCully

4

1 reference

12 August 2017

Melissa L Crane

5

1 reference

12 August 2017

Zhaoxiong Luo

6

1 reference

12 August 2017

An-Yue Tu

7

1 reference

12 August 2017

Brian D Sykes

9

1 reference

12 August 2017

Michael Regnier

10

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12 August 2017

language of work or name

English

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publication date

23 May 2012

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12 August 2017

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12 August 2017

51

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12 August 2017

22

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12 August 2017

4473-4487

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NMR View: A computer program for the visualization and analysis of NMR data

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Visualizing the principal component of ¹H, ¹⁵N-HSQC NMR spectral changes that reflect protein structural or functional properties: application to troponin C.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Thin filament mutations: developing an integrative approach to a complex disorder

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

A suite of Mathematica notebooks for the analysis of protein main chain 15N NMR relaxation data

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

UCSF Chimera--a visualization system for exploratory research and analysis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Molecular and cellular aspects of troponin cardiomyopathies

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Mechanism of cross-bridge detachment in isometric force relaxation of skeletal and cardiac myofibrils

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Kinetic studies of calcium and cardiac troponin I peptide binding to human cardiac troponin C using NMR spectroscopy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Ca2+ - and cross-bridge-dependent changes in N- and C-terminal structure of troponin C in rat cardiac muscle

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

EF-hand calcium-binding proteins.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Conformations of the regulatory domain of cardiac troponin C examined by residual dipolar couplings

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Bepridil opens the regulatory N-terminal lobe of cardiac troponin C

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Regulation of contraction in striated muscle

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

The C terminus of cardiac troponin I is essential for full inhibitory activity and Ca2+ sensitivity of rat myofibrils

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Calcium-induced structural transition in the regulatory domain of human cardiac troponin C

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Mapping of a second actin-tropomyosin and a second troponin C binding site within the C terminus of troponin I, and their importance in the Ca2+-dependent regulation of muscle contraction

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Structure of Cardiac Muscle Troponin C Unexpectedly Reveals a Closed Regulatory Domain

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Kinetic studies of calcium binding to the regulatory site of troponin C from cardiac muscle

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Structures of the troponin C regulatory domains in the apo and calcium-saturated states

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

The interpretation of protein structures: Estimation of static accessibility

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Site-directed mutation of the trigger calcium-binding sites in cardiac troponin C.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Calcium binding proteins. Elucidating the contributions to calcium affinity from an analysis of species variants and peptide fragments

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

The amino acid sequence of troponin I from rabbit skeletal muscle

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Backbone dynamics of SDF-1alpha determined by NMR: interpretation in the presence of monomer-dimer equilibrium

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Biological function and site II Ca2+-induced opening of the regulatory domain of skeletal troponin C are impaired by invariant site I or II Glu mutations

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Calcium-induced conformational change in cardiac troponin C studied by fluorescence probes attached to Cys-84.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Investigation of thin filament near-neighbour regulatory unit interactions during force development in skinned cardiac and skeletal muscle.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Cooperative activation of skeletal and cardiac muscle

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Thin filament near-neighbour regulatory unit interactions affect rabbit skeletal muscle steady-state force-Ca(2+) relations.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Molecular dynamics study of Ca(2+) binding loop variants of parvalbumin with modifications at the "gateway" position

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

Energetics of the induced structural change in a Ca2+ regulatory protein: Ca2+ and troponin I peptide binding to the E41A mutant of the N-domain of skeletal troponin C.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437384

The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation

22 September 2018

1 reference

12 December 2020

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

1 reference

12 December 2020

The fourth EF-hand of calmodulin and its helix-loop-helix components: impact on calcium binding and enzyme activation

1 reference

12 December 2020

The use of model selection in the model-free analysis of protein dynamics

1 reference

12 December 2020

Characterization of troponin-C interactions in skinned barnacle muscle: comparison with troponin-C from rabbit striated muscle

1 reference

12 December 2020

The binding of W7, an inhibitor of striated muscle contraction, to cardiac troponin C

1 reference

12 December 2020

Structure determination by NMR. Isotope labeling

1 reference

12 December 2020

Ca2+-induced conformational transition in the inhibitory and regulatory regions of cardiac troponin I

1 reference

12 December 2020

Observation of microsecond time-scale protein dynamics in the presence of Ln3+ ions: application to the N-terminal domain of cardiac troponin C

1 reference

12 December 2020

Structural and functional significance of aspartic acid 89 of the troponin C central helix in Ca2+ signaling

1 reference

12 December 2020

NMR studies of Ca2+ binding to the regulatory domains of cardiac and E41A skeletal muscle troponin C reveal the importance of site I to energetics of the induced structural changes

1 reference

12 December 2020

Some precautions in using chelators to buffer metals in biological solutions

1 reference

12 December 2020

Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution

1 reference

12 December 2020

Dynamics and thermodynamics of the regulatory domain of human cardiac troponin C in the apo- and calcium-saturated states

1 reference

12 December 2020

Identifiers

DOI

10.1021/BI3003007

1 reference

release_7se7xecuvzfkrosdkywtmwepwa

12 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7se7xecuvzfkrosdkywtmwepwa

24 November 2022

mapped directly with Wikidata item

1 reference

12 August 2017

PubMed publication ID

22591429

1 reference