Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses (Q36234704)

12 August 2017

Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses (English)

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12 August 2017

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Jing He

1

1 reference

12 August 2017

Linda Z Shi

2

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12 August 2017

Lan N Truong

3

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12 August 2017

Chi-Sheng Lu

4

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12 August 2017

Niema Razavian

5

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12 August 2017

Yongjiang Li

6

1 reference

12 August 2017

Alejandro Negrete

7

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12 August 2017

Joseph Shiloach

8

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12 August 2017

Michael W Berns

9

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12 August 2017

Xiaohua Wu

10

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12 August 2017

language of work or name

English

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publication date

25 July 2012

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Journal of Biological Chemistry

12 August 2017

10

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based on heuristic

inferred from page(s)

published in

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12 August 2017

287

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12 August 2017

38

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12 August 2017

31747-31756

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CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

The MRE11 complex: starting from the ends.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Positional stability of single double-strand breaks in mammalian cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Internet-based robotic laser scissors and tweezers microscopy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

DNA damage-dependent nuclear dynamics of the Mre11 complex

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442509

The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

29 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.384750

DNA breaks promote genomic instability by impeding proper chromosome segregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.384750

Telomerase maintains telomere structure in normal human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.384750

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.384750

Chromosome Fragmentation after Induction of a Double-Strand Break Is an Active Process Prevented by the RMX Repair Complex

21 January 2018

2 references

https://api.crossref.org/works/10.1074%2FJBC.M112.384750

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/22833675

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Rad50 hook domain is a critical determinant of Mre11 complex functions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22833675

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.384750

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22833675

1 reference