Sclerostin antibody increases bone volume and enhances implant fixation in a rat model (Q36241657)

13 August 2017

Sclerostin antibody increases bone volume and enhances implant fixation in a rat model (English)

1 reference

13 August 2017

5

Margaret McNulty

1 reference

13 August 2017

Amarjit S Virdi

1

1 reference

13 August 2017

Min Liu

2

1 reference

13 August 2017

Kotaro Sena

3

1 reference

13 August 2017

James Maletich

4

1 reference

13 August 2017

Hua Zhu Ke

6

1 reference

13 August 2017

Dale R Sumner

7

1 reference

13 August 2017

language of work or name

English

0 references

publication date

1 September 2012

1 reference

Journal of Bone and Joint Surgery

13 August 2017

1 reference

13 August 2017

94

1 reference

13 August 2017

18

1 reference

13 August 2017

1670-1680

1 reference

Temporal gene expression profiling during rat femoral marrow ablation-induced intramembranous bone regeneration

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Sclerostin: a gem from the genome leads to bone-building antibodies

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Biology of implant osseointegration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Wnt pathway, an essential role in bone regeneration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

The epidemiology of revision total hip arthroplasty in the United States

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Control of bone mass and remodeling by PTH receptor signaling in osteocytes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Update in osteoporosis and metabolic bone disorders

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Prevalence of primary and revision total hip and knee arthroplasty in the United States from 1990 through 2002.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

LRP5 and Wnt signaling: a union made for bone

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Locally delivered rhBMP-2 enhances bone ingrowth and gap healing in a canine model

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

The efficacy of BMP-2 to induce bone ingrowth in a total hip replacement model

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

BMP signaling components are expressed in human fracture callus

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Aging does not lessen the effectiveness of TGFbeta2-enhanced bone regeneration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

TGF-beta, BMPS, and their signal transducing mediators, Smads, in rat fracture healing

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Locally delivered rhTGF-beta2 enhances bone ingrowth and bone regeneration at local and remote sites of skeletal injury

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Postablation bone marrow regeneration: an in vivo model to study differential regulation of bone formation and resorption.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Gene expression during bone repair.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Enhancement of bone ingrowth by transforming growth factor-beta

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

The susceptibility of smooth implant surfaces to periimplant fibrosis and migration of polyethylene wear debris

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Power and sample size calculations. A review and computer program

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Bone marrow regeneration after local injury: a review

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Role of Wnt signaling in bone remodeling and repair

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

PTH improves titanium implant fixation more than pamidronate or renutrition in osteopenic rats chronically fed a low protein diet

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Effect of alendronate and intermittent parathyroid hormone on implant fixation in ovariectomized rats

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Defective implant osseointegration under protein undernutrition: prevention by PTH or pamidronate.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

The effect of enzymatically degradable IPN coatings on peri-implant bone formation and implant fixation

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Downregulation of SOST/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Global gene profiling reveals a downregulation of BMP gene expression in experimental atrophic nonunions compared to standard healing fractures

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Saline irrigation does not affect bone formation or fixation strength of hydroxyapatite/tricalcium phosphate-coated implants in a rat model.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Stimulation of implant fixation by parathyroid hormone (1-34)-A histomorphometric comparison of PMMA cement and stainless steel.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Local application of rhTGF-beta2 enhances peri-implant bone volume and bone-implant contact in a rat model.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Local application of rhTGF-beta2 modulates dynamic gene expression in a rat implant model.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

A low-temperature biomimetic calcium phosphate surface enhances early implant fixation in a rat model.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Effect of age on the expression of insulin-like growth factor-I, interleukin-6, and transforming growth factor-beta mRNAs in rat femurs following marrow ablation.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

A new electrochemically graded hydroxyapatite coating for osteosynthetic implants promotes implant osteointegration in a rat model

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444952

Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants

21 October 2018

1 reference

12 December 2020

Endosseous implant anchorage is critically dependent on mechanostructural determinants of peri-implant bone trabeculae

1 reference

12 December 2020

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

1 reference

12 December 2020

Expression of bone morphogenetic proteins during mandibular distraction osteogenesis

1 reference

12 December 2020

The effect of hydroxyapatite coating on the bonding of bone to titanium implants in the femora of ovariectomised rats

1 reference

12 December 2020

Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing

1 reference

12 December 2020

Recombinant TGF-beta1 stimulates bone marrow osteoprogenitor cell activity and bone matrix synthesis in osteopenic, old male mice

1 reference

12 December 2020

Implant fixation enhanced by intermittent treatment with parathyroid hormone

1 reference

12 December 2020

Colocalization of noggin and bone morphogenetic protein-4 during fracture healing

1 reference

12 December 2020

Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing

1 reference

12 December 2020

Sclerostin and Wnt signaling--the pathway to bone strength

1 reference

12 December 2020

Early effect of parathyroid hormone (1-34) on implant fixation

1 reference

12 December 2020

Transforming growth factor beta and bone morphogenetic protein 2 for bone ingrowth: a comparison using bone chambers in rats

1 reference

12 December 2020

Sclerostin antibody treatment enhances metaphyseal bone healing in rats

1 reference

12 December 2020

Bone particles disturb new bone formation on the interface of the titanium implant after reaming of the marrow cavity

1 reference

12 December 2020

Impaired bone activity in aged rats: alterations at the cellular and molecular levels

1 reference

12 December 2020

The significance of intramedullary cancellous bone formation in the repair of bone marrow tissue

1 reference

12 December 2020

Pattern of gene expression following rat tibial marrow ablation

1 reference

12 December 2020

Identifiers

DOI

10.2106/JBJS.K.00344

1 reference

13 August 2017

1 reference

13 August 2017

1 reference