Endo/exo-proteolysis in neoplastic progression and metastasis (Q36245383)

13 August 2017

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title

Endo/exo-proteolysis in neoplastic progression and metastasis (English)

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13 August 2017

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L'Houcine Ouafik

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author name string

Abdel-Majid Khatib

1

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13 August 2017

Daniel Bassi

2

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13 August 2017

Geraldine Siegfried

3

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13 August 2017

Andres J P Klein-Szanto

4

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13 August 2017

26 August 2005

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Journal of Molecular Medicine

13 August 2017

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13 August 2017

83

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13 August 2017

11

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13 August 2017

856-864

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https://scigraph.springernature.com/pub.10.1007/s00109-005-0692-y

13 August 2017

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cites work

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Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours

21 January 2018

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Increased furin activity enhances the malignant phenotype of human head and neck cancer cells

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Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme

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Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases

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Lack of integrin alpha-chain endoproteolytic cleavage in furin-deficient human colon adenocarcinoma cells LoVo

21 January 2018

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Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo

21 January 2018

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Synthesis of oligopeptide chloromethanes to investigate extended binding regions of proteinases: application to the interaction of fibrinogen with thrombin

21 January 2018

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Arg15-Lys17-Arg18 turkey ovomucoid third domain inhibits human furin.

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12 December 2020

The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo

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12 December 2020

Regulation of prostatic growth and function by peptide growth factors

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12 December 2020

Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells

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12 December 2020

Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis: involvement of CRLR/RAMP2 and CRLR/RAMP3 receptors

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The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains

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Expression in human lung tumor cells of the proprotein processing enzyme PC1/PC3. Cloning and primary sequence of a 5 kb cDNA.

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12 December 2020

Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin

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12 December 2020

Peptidylglycine alpha-amidating monooxygenase (PAM) immunoreactivity and messenger RNA in human pituitary and increased expression in pituitary tumours.

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12 December 2020

Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase

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12 December 2020

Bombesin increases fetal lung growth and maturation in utero and in organ culture

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12 December 2020

Comparison of peptidyl-glycine alpha-amidation activity in medullary thyroid carcinoma cells, pheochromocytomas, and serum

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12 December 2020

Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

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12 December 2020

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12 December 2020

A protein-based therapeutic for human cytomegalovirus infection

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12 December 2020

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions

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12 December 2020

Curbing activation: proprotein convertases in homeostasis and pathology

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12 December 2020

Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes

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12 December 2020

Human ADAM 12 (meltrin alpha) is an active metalloprotease.

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12 December 2020

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

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12 December 2020

Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration

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12 December 2020

Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture

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12 December 2020

PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium

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12 December 2020

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

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12 December 2020

Expression of adrenomedullin and peptide amidation activity in human prostate cancer and in human prostate cancer cell lines

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12 December 2020

Cloning and characterization of cDNA encoding a precursor for human adrenomedullin

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12 December 2020

Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells

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12 December 2020

ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix

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12 December 2020

Characterization of an alpha-amidating activity in a human pancreatic tumour secreting vasoactive intestinal peptide (VIP)

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12 December 2020

Furin at the cutting edge: from protein traffic to embryogenesis and disease

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12 December 2020

Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancer.

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12 December 2020

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

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12 December 2020

Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases

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12 December 2020

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

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12 December 2020

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant

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12 December 2020

Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene

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12 December 2020

Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection

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12 December 2020

Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells

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12 December 2020

Androgen-independent expression of adrenomedullin and peptidylglycine α-amidating monooxygenase in human prostatic carcinoma

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12 December 2020

New insights into copper monooxygenases and peptide amidation: structure, mechanism and function

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12 December 2020

Role of endoproteolytic processing in the adhesive and signaling functions of alphavbeta5 integrin

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12 December 2020

Phase I and imaging trial of a monoclonal antibody directed against gastrin-releasing peptide in patients with lung cancer.

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12 December 2020

Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology

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12 December 2020

Localization of the gene encoding peptidylglycine alpha-amidating monooxygenase (PAM) to human chromosome 5q14-5q21

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12 December 2020

Mucinous carcinoma of the breast. A clinicopathologic, histochemical, and immunocytochemical study with special reference to neuroendocrine differentiation

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12 December 2020

The biosynthesis of neuropeptides: peptide alpha-amidation

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12 December 2020

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

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12 December 2020

Chemical determination of polypeptide hormones

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12 December 2020

Androgen-independent growth is induced by neuropeptides in human prostate cancer cell lines

1 reference

12 December 2020

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

1 reference

12 December 2020

Adrenomedullin, a multifunctional regulatory peptide

1 reference

12 December 2020

Autocrine growth loops dependent on peptidyl alpha-amidating enzyme as targets for novel tumor cell growth inhibitors

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12 December 2020

Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage

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12 December 2020

Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis.

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12 December 2020

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

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12 December 2020

Role of transforming growth factor beta in cancer

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12 December 2020

Prostatic cell lineage markers: emergence of BCL2+ cells of human prostate cancer xenograft LuCaP 23 following castration.

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12 December 2020

Circulating proalbumin associated with a variant proteinase inhibitor

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12 December 2020

Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer.

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12 December 2020

Epigenetic regulation of proprotein convertase PACE4 gene expression in human ovarian cancer cells

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12 December 2020

fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas

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12 December 2020

Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.

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12 December 2020

Two enzymes concerned in peptide hormone α-amidation are synthesized from a single mRNA

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12 December 2020

alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

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12 December 2020

Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness.

1 reference

12 December 2020

Structure-function analysis of the prosegment of the proprotein convertase PC5A.

1 reference

12 December 2020

Leukocyte-endothelial adhesion molecules

1 reference

12 December 2020

The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation

1 reference

12 December 2020

Interactions between tumour cells and stromal cells and proteolytic modification of the extracellular matrix by metalloproteinases in cancer.

1 reference

12 December 2020

10.1007/S00109-005-0692-Y

Identifiers

DOI

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13 August 2017

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