Signal transduction of oncogenic Flt3. (Q36251180)

13 August 2017

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title

Signal transduction of oncogenic Flt3. (English)

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13 August 2017

2

Carsten Müller-Tidow

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author name string

Chunaram Choudhary

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1

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13 August 2017

Wolfgang E Berdel

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3

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13 August 2017

Hubert Serve

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4

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13 August 2017

1 August 2005

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International Journal of Hematology

13 August 2017

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13 August 2017

82

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13 August 2017

2

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13 August 2017

93-99

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https://scigraph.springernature.com/pub.10.1532/ijh97.05090

13 August 2017

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cites work

Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML).

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12 December 2020

FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

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Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

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A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse

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12 December 2020

Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations

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AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

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12 December 2020

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain

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Oncogenic kinase signalling

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12 December 2020

Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells

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12 December 2020

FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins

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Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

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Transcriptional regulation of granulocyte and monocyte development

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Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

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Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase

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12 December 2020

FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases.

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12 December 2020

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

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Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations

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Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.

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Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages

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The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

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Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

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12 December 2020

Flt3 receptor tyrosine kinase as a drug target in leukemia

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12 December 2020

Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase

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12 December 2020

Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias

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12 December 2020

FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells

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12 December 2020

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

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12 December 2020

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

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12 December 2020

Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

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12 December 2020

Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.

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12 December 2020

Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells

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12 December 2020

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia

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12 December 2020

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

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Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

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12 December 2020

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

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12 December 2020

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

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12 December 2020

Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors

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12 December 2020

Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

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12 December 2020

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

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12 December 2020

The roles of FLT3 in hematopoiesis and leukemia

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12 December 2020

The role of FLT3 in haematopoietic malignancies

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12 December 2020

C-kit mutations in core binding factor leukemias

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12 December 2020

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

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12 December 2020

Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases

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12 December 2020

Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).

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12 December 2020

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation

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12 December 2020

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

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12 December 2020

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

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12 December 2020

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia

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12 December 2020

Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis

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12 December 2020

STAT3 is required for Flt3L-dependent dendritic cell differentiation.

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12 December 2020

Sequential protein kinase reactions controlling cell growth and differentiation

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12 December 2020

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

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12 December 2020

FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor FoxO3.

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12 December 2020

The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

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12 December 2020

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

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12 December 2020

Prognostic significance of FLT3 ITD and D835 mutations in AML patients

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12 December 2020

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

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12 December 2020

A gain-of-function mutation of JAK2 in myeloproliferative disorders

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12 December 2020

SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor

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12 December 2020

Signal transducer and activator of transcription proteins in leukemias.

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12 December 2020

p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells

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12 December 2020

Switching signals on or off by receptor dimerization

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12 December 2020

The importance of PU.1 concentration in hematopoietic lineage commitment and maturation

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12 December 2020

Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia

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12 December 2020

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12 December 2020

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

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12 December 2020

Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia

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12 December 2020

A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657.

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12 December 2020

Characterization of the protein encoded by the flt3 (flk2) receptor-like tyrosine kinase gene

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12 December 2020

Stat5 tetramer formation is associated with leukemogenesis

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12 December 2020

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

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12 December 2020

Structure of a c-kit product complex reveals the basis for kinase transactivation

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12 December 2020

Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor

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12 December 2020

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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12 December 2020

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

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12 December 2020

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

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12 December 2020

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells

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12 December 2020

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

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12 December 2020

The phosphoinositide 3-kinase pathway

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12 December 2020

Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

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12 December 2020

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

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12 December 2020

Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation

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12 December 2020

Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia

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12 December 2020

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

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12 December 2020

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

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12 December 2020

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12 December 2020

Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias

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12 December 2020

FLT3 mutations in childhood acute lymphoblastic leukemia

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12 December 2020

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

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12 December 2020

Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells

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12 December 2020

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

1 reference

12 December 2020

Identifiers

DOI

10.1532/IJH97.05090

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Dimensions Publication ID

13 August 2017

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