Human antibodies from transgenic animals (Q36252986)

13 August 2017

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title

Human antibodies from transgenic animals (English)

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13 August 2017

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Nils Lonberg

1

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13 August 2017

1 September 2005

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13 August 2017

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13 August 2017

23

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13 August 2017

1117-1125

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13 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nbt1135

13 August 2017

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cites work

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High efficiency creation of human monoclonal antibody-producing hybridomas

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Increased frequency of both total and specific monoclonal antibody producing hybridomas using a fusion partner that constitutively expresses recombinant IL-6.

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An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus.

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Continuous cultures of fused cells secreting antibody of predefined specificity

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A repertoire of monoclonal antibodies with human heavy chains from transgenic mice

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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

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Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

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Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

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Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

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Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.

21 January 2018

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The creation of diversity in the human immunoglobulin V(lambda) repertoire

21 January 2018

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The evolutionary and structural 'logic' of antigen receptor diversity

21 January 2018

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Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities

21 January 2018

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Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations

21 January 2018

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Correlation of the Km(1) immunoglobulin allotype with anti-polysaccharide antibodies in Caucasian adults

21 January 2018

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A defective Vkappa A2 allele in Navajos which may play a role in increased susceptibility to haemophilus influenzae type b disease

21 January 2018

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High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice.

21 January 2018

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Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

21 January 2018

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Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes

21 January 2018

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Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies

21 January 2018

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Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

21 January 2018

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A human immunoglobulin lambda locus is similarly well expressed in mice and humans

21 January 2018

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Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain.

21 January 2018

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Silencing of the immunoglobulin heavy chain locus by removal of all eight constant-region genes in a 200-kb region.

21 January 2018

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Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis

21 January 2018

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Antibody therapy in the management of shiga toxin-induced hemolytic uremic syndrome

21 January 2018

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Production and characterization of protective human antibodies against Shiga toxin 1

21 January 2018

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Human Stx2-specific monoclonal antibodies prevent systemic complications of Escherichia coli O157:H7 infection

21 January 2018

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Efficient isolation of novel human monoclonal antibodies with neutralizing activity against HIV-1 from transgenic mice expressing human Ig loci

21 January 2018

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Structure-function relationships for human antibodies to pneumococcal capsular polysaccharide from transgenic mice with human immunoglobulin Loci

21 January 2018

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Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles

21 January 2018

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Production of human monoclonal and polyclonal antibodies in TransChromo animals

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Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

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A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women

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Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma

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A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis

21 January 2018

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Human monoclonal antibodies produced in transgenic BABkappa,lambda mice recognising idiotypic immunoglobulins of human lymphoma cells.

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HuMax-CD4: a fully human monoclonal anti-CD4 antibody for the treatment of psoriasis vulgaris.

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Differential effects of administration of a human anti-CD4 monoclonal antibody, HM6G, in nonhuman primates

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Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

21 January 2018

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Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation

21 January 2018

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Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy

21 January 2018

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Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer.

21 January 2018

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Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

21 January 2018

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Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy

21 January 2018

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PSMA specific antibodies and their diagnostic and therapeutic use.

21 January 2018

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Combination of the human anti-CD30 antibody 5F11 with cytostatic drugs enhances its antitumor activity against Hodgkin and anaplastic large cell lymphoma cell lines

21 January 2018

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Mannose receptor targeting of tumor antigen pmel17 to human dendritic cells directs anti-melanoma T cell responses via multiple HLA molecules

21 January 2018

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Activity and safety of CTLA-4 blockade combined with vaccines in cynomolgus macaques

21 January 2018

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Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma

21 January 2018

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HMOCC-1, a human monoclonal antibody that inhibits adhesion of ovarian cancer cells to human mesothelial cells

21 January 2018

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Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2

21 January 2018

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Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers

21 January 2018

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CNTO 95, a fully human monoclonal antibody that inhibits alphav integrins, has antitumor and antiangiogenic activity in vivo

21 January 2018

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HMMC-1: a humanized monoclonal antibody with therapeutic potential against Müllerian duct-related carcinomas

21 January 2018

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Kinetic and affinity limits on antibodies produced during immune responses

21 January 2018

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Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity

21 January 2018

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Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody

21 January 2018

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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

21 January 2018

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Clinical experience with monoclonal antibodies to epidermal growth factor receptor

21 January 2018

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Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

21 January 2018

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Role of dendritic cell phenotype, determinant spreading, and negative costimulatory blockade in dendritic cell-based melanoma immunotherapy

21 January 2018

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Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

21 January 2018

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Enhancement of antitumor immunity by CTLA-4 blockade

21 January 2018

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Anti-interleukin-12 antibody for active Crohn's disease

21 January 2018

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Structure-immunogenicity relationships of therapeutic proteins

21 January 2018

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Destabilizing loop swaps in the CDRs of an immunoglobulin VL domain

21 January 2018

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Idiopathic thrombocytopenic purpura in pregnancy. Successful management with immunoglobulin infusion

21 January 2018

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Sequential targeting of the genes encoding immunoglobulin-mu and prion protein in cattle

21 January 2018

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Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease

21 January 2018

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The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes

21 January 2018

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Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies

21 January 2018

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Antigen-specific human antibodies from mice comprising four distinct genetic modifications

21 January 2018

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Estimation of the indirect effect of Haemophilus influenzae type b conjugate vaccine in an American Indian population

21 January 2018

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7 January 2021

Functional expression and germline transmission of a human chromosome fragment in chimaeric mice

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7 January 2021

The human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against malignant lymphoma

1 reference

7 January 2021

Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen

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7 January 2021

Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis

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7 January 2021

A prospective randomized study of prophylactic OKT3 versus equine antithymocyte globulin after heart transplantation--increased morbidity with OKT3.

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7 January 2021

Cloned transchromosomic calves producing human immunoglobulin

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7 January 2021

Identifiers

DOI

10.1038/NBT1135

1 reference

PubMed ID

16151405

Dimensions Publication ID

13 August 2017

0 references

1 reference

PubMed ID

16151405