Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme (Q36266912)

13 August 2017

Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme (English)

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13 August 2017

1 reference

ChEBI release 2020-05-28

Choong-Soo Yun

1

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13 August 2017

Takayuki Motoyama

series ordinal

2

1 reference

13 August 2017

Hiroyuki Osada

series ordinal

3

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13 August 2017

language of work or name

English

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publication date

27 October 2015

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13 August 2017

Nature Communications

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13 August 2017

6

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13 August 2017

8758

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Creative Commons Attribution 4.0 International

13 August 2017

start time

27 October 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Reconstructing fungal natural product biosynthetic pathways

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Phylogenetic study of polyketide synthases and nonribosomal peptide synthetases involved in the biosynthesis of mycotoxins

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Molecular diversity sculpted by fungal PKS-NRPS hybrids

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The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin

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Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain

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Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria

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Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

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Characterization of cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase in cyclopiazonic acid biosynthesis: substrate promiscuity and site directed mutagenesis studies

30 September 2017

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The biosynthetic logic of polyketide diversity

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A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans

30 September 2017

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Biosynthesis of secondary metabolites in the rice blast fungus Magnaporthe grisea: the role of hybrid PKS-NRPS in pathogenicity

30 September 2017

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Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

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Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana.

30 September 2017

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Structure and biosynthesis of heat-stable antifungal factor (HSAF), a broad-spectrum antimycotic with a novel mode of action

30 September 2017

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Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

30 September 2017

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Studies in the biochemistry of micro-organisms. 108. Metabolites of Alternaria tenuis Auct.: the biosynthesis of tenuazonic acid

30 September 2017

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The genome sequence of the rice blast fungus Magnaporthe grisea

30 September 2017

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Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum.

30 September 2017

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Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

30 September 2017

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Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases.

30 September 2017

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Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules

30 September 2017

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Structural control of polyketide formation in plant-specific polyketide synthases

30 September 2017

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Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase

30 September 2017

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New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.

30 September 2017

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

30 September 2017

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Yeast/E. coli shuttle vectors with multiple unique restriction sites

30 September 2017

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Navigating the fungal polyketide chemical space: from genes to molecules.

30 September 2017

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Chromatin-level regulation of biosynthetic gene clusters

30 September 2017

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Structural basis for the formation of acylalkylpyrones from two β-ketoacyl units by the fungal type III polyketide synthase CsyB.

30 September 2017

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In vitro reconstruction of tetronate RK-682 biosynthesis

29 June 2018

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Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases

29 June 2018

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Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.

29 June 2018

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Studies in the biochemistry of micro-organisms. 103. Metabolites of Alternaria tenuis auct; culture filtrate products

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Agrobacterium tumefaciens-mediated transformation of filamentous fungi

29 June 2018

1 reference

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Paenilamicin: structure and biosynthesis of a hybrid nonribosomal peptide/polyketide antibiotic from the bee pathogen Paenibacillus larvae.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Large-scale synthesis of isotopically labeled 13C2-tenuazonic acid and development of a rapid HPLC-MS/MS method for the analysis of tenuazonic acid in tomato and pepper products

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Quartromicin biosynthesis: two alternative polyketide chains produced by one polyketide synthase assembly line

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Determination of the Alternaria mycotoxin tenuazonic acid in cereals by high-performance liquid chromatography-electrospray ionization ion-trap multistage mass spectrometry after derivatization with 2,4-dinitrophenylhydrazine

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Thioesterase-like role for fungal PKS-NRPS hybrid reductive domains

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires coexpression with an enoyl reductase.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

A two-component histidine kinase of the rice blast fungus is involved in osmotic stress response and fungicide action

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

A putative polyketide synthase/peptide synthetase from Magnaporthe grisea signals pathogen attack to resistant rice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Enzymatic characterization of scytalone dehydratase Val75Met variant found in melanin biosynthesis dehydratase inhibitor (MBI-D) resistant strains of the rice blast fungus

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Agrobacterium tumefaciens-mediated transformation of the plant pathogenic fungus, Magnaporthe grisea

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Properties and substrate specificity of RppA, a chalcone synthase-related polyketide synthase in Streptomyces griseus.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

cDNA cloning, expression, and mutagenesis of scytalone dehydratase needed for pathogenicity of the rice blast fungus, Pyricularia oryzae

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640141

Independent Signaling Pathways Regulate Cellular Turgor during Hyperosmotic Stress and Appressorium-Mediated Plant Infection by Magnaporthe grisea

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS9758

Antiviral Activity of Tenuazonic Acid

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS9758

Antitumor, Cytotoxic, and Antibacterial Activities of Tenuazonic Acid and Congeneric Tetramic Acids1

21 January 2018

1 reference

12 December 2020

Hidden biosynthetic treasures brought to light

1 reference

12 December 2020

Enzyme immunoassay for tenuazonic acid in apple and tomato products

1 reference

12 December 2020

THE BIOLOGICAL ACTIVITY OF TENUAZONIC ACID

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS9758

1 reference

13 August 2017

0 references

1 reference

13 August 2017

PubMed publication ID

26503170

1 reference