Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27. (Q36283378)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26336106%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

title

Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27 (English)

1 reference

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23 February 2020

author

Miquéias Lopes-Pacheco

1

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23 February 2020

6

Liudmila Cebotaru

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23 February 2020

5

William B Guggino

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23 February 2020

author name string

Clément Boinot

2

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23 February 2020

Inna Sabirzhanova

3

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23 February 2020

Marcelo M Morales

4

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23 February 2020

language of work or name

English

0 references

publication date

2 September 2015

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Journal of Biological Chemistry

23 February 2020

published in

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23 February 2020

volume

290

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23 February 2020

issue

42

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23 February 2020

page(s)

25636-25645

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Correcting the cystic fibrosis disease mutant, A455E CFTR

23 February 2020

cites work

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Mechanism-based corrector combination restores ΔF508-CFTR folding and function

30 September 2017

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Transcomplementation by a truncation mutant of cystic fibrosis transmembrane conductance regulator (CFTR) enhances ΔF508 processing through a biomolecular interaction

30 September 2017

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Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway

30 September 2017

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Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

30 September 2017

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30 September 2017

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Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation.

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Sensitivity of chloride efflux vs. transepithelial measurements in mixed CF and normal airway epithelial cell populations

30 September 2017

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The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain

30 September 2017

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Modeling general proteostasis: proteome balance in health and disease

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Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation

30 September 2017

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Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry

30 September 2017

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Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

30 September 2017

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CFTR function and prospects for therapy

30 September 2017

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Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation

30 September 2017

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Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

30 September 2017

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Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

30 September 2017

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CFTR and chaperones: processing and degradation.

30 September 2017

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Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

30 September 2017

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The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70

30 September 2017

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30 September 2017

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30 September 2017

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22 September 2018

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22 September 2018

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The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26336106

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clinical implications of cystic fibrosis transmembrane conductance regulator mutations

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26336106

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M115.671925

1 reference

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23 February 2020

1 reference

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23 February 2020

PubMed publication ID

26336106

1 reference