ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading (Q36298311)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22898811%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading (English)

1 reference

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Solute carrier family 39 member 8

11 February 2020

main subject

1 reference

iron ion import across plasma membrane

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

0 references

5

1 reference

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11 February 2020

Bryan Mackenzie

6

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11 February 2020

4

Brian K Sparkman

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11 February 2020

7

Mitchell D Knutson

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11 February 2020

author name string

Chia-Yu Wang

1

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11 February 2020

Supak Jenkitkasemwong

2

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11 February 2020

Stephanie Duarte

3

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11 February 2020

language of work or name

English

0 references

publication date

16 August 2012

1 reference

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Journal of Biological Chemistry

11 February 2020

published in

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11 February 2020

volume

287

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11 February 2020

page(s)

34032-34043

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11 February 2020

issue

41

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Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1.

11 February 2020

cites work

1 reference

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ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero

30 September 2017

1 reference

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The zinc transporter Zip14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice

30 September 2017

1 reference

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Physiologic implications of metal-ion transport by ZIP14 and ZIP8

30 September 2017

1 reference

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Role of the placenta in regulation of fetal iron status

30 September 2017

1 reference

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Effect of dietary iron deficiency and overload on the expression of ZIP metal-ion transporters in rat liver

30 September 2017

1 reference

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Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron.

30 September 2017

1 reference

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Molecular and genetic features of zinc transporters in physiology and pathogenesis.

30 September 2017

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The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth

30 September 2017

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ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin

30 September 2017

1 reference

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Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells

30 September 2017

1 reference

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Mammalian zinc transporters: nutritional and physiologic regulation

30 September 2017

1 reference

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The use of BeWo cells as an in vitro model for placental iron transport

30 September 2017

1 reference

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Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter

30 September 2017

1 reference

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Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)

30 September 2017

1 reference

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Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line

30 September 2017

1 reference

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A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Influence of parenteral iron preparations on non-transferrin bound iron uptake, the iron regulatory protein and the expression of ferritin and the divalent metal transporter DMT-1 in HepG2 human hepatoma cells.

30 September 2017

1 reference

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Role of non-transferrin-bound iron in the pathogenesis of iron overload and toxicity

30 September 2017

1 reference

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Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures

30 September 2017

1 reference

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Cadmium overload and toxicity

30 September 2017

1 reference

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Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells

30 September 2017

1 reference

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Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins

30 September 2017

1 reference

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Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

30 September 2017

1 reference

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Cloning and characterization of a mammalian proton-coupled metal-ion transporter

30 September 2017

1 reference

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A novel iron-regulated metal transporter from plants identified by functional expression in yeast.

30 September 2017

1 reference

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Health risks associated with cobalt exposure--an overview

30 September 2017

1 reference

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Trace elements in human body fluids and tissues

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Uptake and subcellular processing of 59Fe-125I-labelled transferrin by rat liver

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Release of iron from ferritin requires lysosomal activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

The metal permease ZupT from Escherichia coli is a transporter with a broad substrate spectrum

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Interrelationship of cobalt and iron absorption

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Targeting of the mouse Slc39a2 (Zip2) gene reveals highly cell-specific patterns of expression, and unique functions in zinc, iron, and calcium homeostasis.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine

22 September 2018

1 reference

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Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Arabidopsis IRT2 gene encodes a root-periphery iron transporter

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes: implications for the pathogenesis of iron-overload disease.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Influence of iron overload on manganese, zinc, and copper concentration in rat tissues in vivo: study of liver, spleen, and brain.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464513

Stimulation of NADH oxidation by xanthine oxidase and polyvanadate in presence of some dehydrogenases and flavin compounds

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.367284

Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice

21 January 2018

1 reference

12 December 2020

T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice

1 reference

12 December 2020

Generation of epitope-tagged proteins by inverse polymerase chain reaction mutagenesis

1 reference

12 December 2020

Alteration in cobalt absorption in patients with disorders of iron metabolism

1 reference

12 December 2020

Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy

1 reference

12 December 2020

Transferrin receptor expression in normal, iron-deficient and iron-overloaded rats

1 reference

12 December 2020

Mobilization of iron from endocytic vesicles. The effects of acidification and reduction

1 reference

12 December 2020

Hepatic zinc in hemochromatosis

1 reference

12 December 2020

Transferrin receptor expression and the regulation of placental iron uptake

1 reference

12 December 2020

Effects of iron loading on uptake, speciation, and chelation of iron in cultured myocardial cells

1 reference

12 December 2020

Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M112.367284

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22898811%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22898811%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference