Sequence of late molecular events in the activation of rhodopsin (Q36299903)

13 August 2017

Sequence of late molecular events in the activation of rhodopsin (English)

1 reference

13 August 2017

4

Wayne L Hubbell

1 reference

13 August 2017

2

Klaus Peter Hofmann

1 reference

13 August 2017

Bernhard Knierim

1

1 reference

PMCID

2154424

13 August 2017

Oliver P Ernst

series ordinal

3

1 reference

PMCID

2154424

13 August 2017

language of work or name

English

0 references

publication date

11 December 2007

1 reference

Proceedings of the National Academy of Sciences of the United States of America

13 August 2017

1 reference

13 August 2017

104

1 reference

13 August 2017

51

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13 August 2017

20290-20295

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Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Visual rhodopsin sees the light: structure and mechanism of G protein signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

G-protein alpha and beta-gamma subunits interact with conformationally distinct signaling states of rhodopsin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Structural basis of function in heterotrimeric G proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Conformational states and dynamics of rhodopsin in micelles and bilayers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Solutes modify a conformational transition in a membrane transport protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Molecular mechanism of 7TM receptor activation--a global toggle switch model

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Structure of bovine rhodopsin in a trigonal crystal form.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Historical review: a brief history and personal retrospective of seven-transmembrane receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

TAUTOMERIC FORMS OF METARHODOPSIN.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Active states of rhodopsin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Structure and orientation of a G protein fragment in the receptor bound state from residual dipolar couplings

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Activation of rhodopsin: new insights from structural and biochemical studies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Maximal rate and nucleotide dependence of rhodopsin-catalyzed transducin activation: initial rate analysis based on a double displacement mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Identifying conformational changes with site-directed spin labeling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Signal transfer from rhodopsin to the G-protein: evidence for a two-site sequential fit mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Light-activated rhodopsin induces structural binding motif in G protein alpha subunit

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Mechanisms of opsin activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Complex formation between metarhodopsin II and GTP-binding protein in bovine photoreceptor membranes leads to a shift of the photoproduct equilibrium

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Proton concentration jumps and generation of transmembrane pH-gradients by photolysis of 4-formyl-6-methoxy-3-nitrophenoxyacetic acid

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Evidence for differently protonated forms of metarhodopsin II as intermediates in the decay of membrane-bound cattle rhodopsin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Structure and function of proteins in G-protein-coupled signal transfer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

The carboxyl terminus of the Galpha-subunit is the latch for triggered activation of heterotrimeric G proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

A rectangular loop-gap resonator for EPR studies of aqueous samples.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154424

Proton transfer reactions linked to rhodopsin activation.

29 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Direct observation of the complex formation of GDP-bound transducin with the rhodopsin intermediate having a visible absorption maximum in rod outer segment membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Sequence of interactions in receptor-G protein coupling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Signal transfer from GPCRs to G proteins: role of the G alpha N-terminal region in rhodopsin-transducin coupling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin-labeling study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Monitoring proton uptake from aqueous phase during rhodopsin activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Signaling states of rhodopsin. Retinal provides a scaffold for activating proton transfer switches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Rhodopsin-transducin coupling: role of the Galpha C-terminus in nucleotide exchange catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710393104

Optical study of the light-induced protonation changes associated with the metarhodopson II intermediate in rod-outer-segment membranes

21 January 2018

1 reference

12 December 2020

Shift in the relation between flash‐induced metarhodopsin I and metarhodopsin II within the first 10% rhodopsin bleaching in bovine disc membranes

1 reference

12 December 2020

Proton uptake by light induced interaction between rhodopsin and G-protein

1 reference

12 December 2020

Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit

1 reference

12 December 2020

Formation of the meta II photointermediate is accompanied by conformational changes in the cytoplasmic surface of rhodopsin

1 reference

12 December 2020

Photoactivated conformational changes in rhodopsin: a time-resolved spin label study

1 reference

12 December 2020

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

1 reference

12 December 2020

A single amino acid substitution in rhodopsin (lysine 248----leucine) prevents activation of transducin

1 reference

12 December 2020

The molecular origin of the inhibition of transducin activation in rhodopsin lacking the 9-methyl group of the retinal chromophore: a UV-Vis and FTIR spectroscopic study

1 reference

12 December 2020

Transducin-dependent protonation of glutamic acid 134 in rhodopsin

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0710393104

1 reference

13 August 2017

0 references

1 reference

13 August 2017

1 reference

PMCID

2154424