Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells (Q36305220)

13 August 2017

Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells (English)

1 reference

13 August 2017

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1

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8 June 2020

Hisham Bahmad

5

1 reference

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8 June 2020

Georges Daoud

8

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8 June 2020

Firas Kobeissy

10

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8 June 2020

author name string

Amaly Nokkari

2

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8 June 2020

Muhieddine M Itani

3

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8 June 2020

Farah Chamaa

4

1 reference

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8 June 2020

Alissar Monzer

6

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8 June 2020

Rabih El-Merahbi

7

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8 June 2020

Assaad Eid

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26635517%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Wassim Abou-Kheir

11

1 reference

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8 June 2020

publication date

23 November 2015

1 reference

Frontiers in Neuroscience

13 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26635517%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

9

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8 June 2020

page(s)

442

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CCL18 from tumor-cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway

8 June 2020

cites work

1 reference

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Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways.

30 September 2017

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PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

30 September 2017

1 reference

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Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo

30 September 2017

1 reference

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Purine Analogues as Kinase Inhibitors: A Review

30 September 2017

1 reference

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Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women

30 September 2017

1 reference

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Epigenetic Regulation of miRNAs and Breast Cancer Stem Cells

30 September 2017

1 reference

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Small molecule regulation of normal and leukemic stem cells

30 September 2017

1 reference

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A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors.

30 September 2017

1 reference

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TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells

30 September 2017

1 reference

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Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

30 September 2017

1 reference

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Hematopoietic stem cells: cancer involvement and myeloid leukemia

30 September 2017

1 reference

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Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment.

30 September 2017

1 reference

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Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells

30 September 2017

1 reference

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Antidiabetic drug metformin inhibits esophageal adenocarcinoma cell proliferation in vitro and in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators

30 September 2017

1 reference

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Metformin association with lower prostate cancer recurrence in type 2 diabetes: a systematic review and meta-analysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Strategies of eradicating glioma cells: a multi-scale mathematical model with MiR-451-AMPK-mTOR control

30 September 2017

1 reference

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Neuroblastoma: paradigm for precision medicine

30 September 2017

1 reference

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Berberis libanotica Ehrenb extract shows anti-neoplastic effects on prostate cancer stem/progenitor cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Glioma stem cells: markers, hallmarks and therapeutic targeting by metformin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

5'-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model

30 September 2017

1 reference

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Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.

30 September 2017

1 reference

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Inhibition of AMPK catabolic action by GSK3.

30 September 2017

1 reference

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Mechanisms of chemoresistance in cancer stem cells

30 September 2017

1 reference

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Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

A restricted cell population propagates glioblastoma growth after chemotherapy

30 September 2017

1 reference

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Cancer stem cells: impact, heterogeneity, and uncertainty

30 September 2017

1 reference

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The role of cancer stem cells in relapse of solid tumors

30 September 2017

1 reference

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Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity

30 September 2017

1 reference

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AMP-activated protein kinase attenuates Wnt/β-catenin signaling in human osteoblastic Saos-2 cells

30 September 2017

1 reference

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Cells of origin in cancer

30 September 2017

1 reference

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

AMPK inhibition in health and disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

30 September 2017

1 reference

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Molecularly targeted therapy for malignant glioma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Standard treatment and experimental targeted drug therapy for recurrent glioblastoma multiforme.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Characteristics of stem cells from human neuroblastoma cell lines and in tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Vidarabin-monophosphate, BCNU, VM26--an in vitro comparative study of active agents in the treatment of malignant human brain tumours

30 September 2017

1 reference

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Targeting Wnt pathway in mantle cell lymphoma-initiating cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Characterizing the contribution of stem/progenitor cells to tumorigenesis in the Pten-/-TP53-/- prostate cancer model

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Therapy of malignant brain tumors: comparison of the in vitro activities of vidarabin-monophosphate, BCNU and 5-fluorouracil.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Arsenic trioxide synergistically potentiates the cytotoxic effect of fludarabine in chronic lymphocytic leukemia cells by further inactivating the Akt and ERK signaling pathways.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Association between metformin therapy and incidence, recurrence and mortality of prostate cancer: evidence from a meta-analysis.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Glioblastoma stem cells: a new target for metformin and arsenic trioxide.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Recent advances in neuroblastoma

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Comparison of the actions of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 9-beta-D-arabinofuranosyladenine on target enzymes from mouse tumor cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655242

Childhood cancer survival in Europe and the United States

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFNINS.2015.00442

Metformin Association with Lower Prostate Cancer Recurrence in Type 2 Diabetes: a Systematic Review and Meta-analysis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFNINS.2015.00442

Biologic factors determine prognosis in infants with stage IV neuroblastoma: A prospective Children's Cancer Group study

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26635517

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FNINS.2015.00442

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26635517%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26635517%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26635517%20AND%20SRC:MED&resulttype=core&format=json