Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis (Q36311399)

13 August 2017

Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis (English)

1 reference

Francisco J Sánchez-Gómez

13 August 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

Fernando Rodríguez-Pascual

7 June 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Matilde Alique

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Marta Ruiz-Ortega

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Marta Ruiz-Ortega

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Naiara Beraza

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

Maria Luz Martinez Chantar

7 June 2020

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Santiago Lamas

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Cristina Espinosa-Diez

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Marta Fierro-Fernández

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Carlos Fernández-Hernando

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

29 October 2014

1 reference

Antioxidants & Redox Signaling

13 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

1092-1105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney

7 June 2020

cites work

1 reference

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Involvement of Nrf2-GSH signaling in TGFβ1-stimulated epithelial-to-mesenchymal transition changes in rat renal tubular cells

30 September 2017

1 reference

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Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis

30 September 2017

1 reference

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Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

30 September 2017

1 reference

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The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

30 September 2017

1 reference

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Hydrogen peroxide signaling in vascular endothelial cells.

30 September 2017

1 reference

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Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo

30 September 2017

1 reference

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FibromiRs: translating molecular discoveries into new anti-fibrotic drugs

30 September 2017

1 reference

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The use of microRNAs to modulate redox and immune response to stroke

30 September 2017

1 reference

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Obstructive renal injury: from fluid mechanics to molecular cell biology

30 September 2017

1 reference

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Unilateral ureteral obstruction: beyond obstruction.

30 September 2017

1 reference

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S-glutathionylation: relevance in diabetes and potential role as a biomarker.

30 September 2017

1 reference

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Endothelial dysfunction - a major mediator of diabetic vascular disease

30 September 2017

1 reference

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Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.

30 September 2017

1 reference

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Oxidative stress and microRNAs in vascular diseases.

30 September 2017

1 reference

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Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis

30 September 2017

1 reference

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The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo

30 September 2017

1 reference

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Differential regulation of γ-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: γ-glutamyltransferase is regulated in an Nrf2- and NFκB-independent manner

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

miRNAs in endothelial cell signaling: the endomiRNAs

30 September 2017

1 reference

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Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis.

30 September 2017

1 reference

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Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells

30 September 2017

1 reference

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Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells

30 September 2017

1 reference

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The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

The functions of microRNAs in pluripotency and reprogramming.

30 September 2017

1 reference

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30 September 2017

Glutathione synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Role of microRNA processing in adipose tissue in stress defense and longevity

30 September 2017

1 reference

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Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis

30 September 2017

1 reference

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Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice

30 September 2017

1 reference

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Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model

30 September 2017

1 reference

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30 September 2017

MicroRNAs and fibrosis

1 reference

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Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging

30 September 2017

1 reference

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S-Glutathionylation signaling in cell biology: progress and prospects

30 September 2017

1 reference

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RNA modifications by oxidation: a novel disease mechanism?

30 September 2017

1 reference

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Role of microRNAs in endothelial cell pathophysiology

30 September 2017

1 reference

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Biological functions of microRNAs: a review

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Mammalian microRNAs predominantly act to decrease target mRNA levels

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Rapid activation of glutamate cysteine ligase following oxidative stress

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Fluorescent protein-based redox probes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

MicroRNAs: target recognition and regulatory functions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Toward microRNA-based therapeutics for heart disease: the sense in antisense

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Regulation of glutathione synthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Real-time imaging of the intracellular glutathione redox potential.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

New biomarkers of acute kidney injury

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Epigallocatechin-3-gallate inhibits growth of activated hepatic stellate cells by enhancing the capacity of glutathione synthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

MicroRNAs: genomics, biogenesis, mechanism, and function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Glutathionylation of proteins by glutathione disulfide S-oxide

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

microRNAs: tiny regulators with great potential

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Glutathione metabolism and its selective modification

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Glutathione regulates transforming growth factor-beta-stimulated collagen production in fibroblasts

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Regulation of gamma-glutamylcysteine synthetase by protein phosphorylation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Loss of suppression of GSH synthesis at low cell density in primary cultures of rat hepatocytes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

miRNA overexpression induces cardiomyocyte proliferation in vivo

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanisms

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Endothelium-dependent vasorelaxation in inhibited by in vivo depletion of vascular thiol levels: role of endothelial nitric oxide synthase

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657521

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25353619

12 December 2020

inferred from PubMed ID database lookup

Cholestatic liver injury down-regulates hepatic glutathione synthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25353619

12 December 2020

inferred from PubMed ID database lookup

Gamma-glutamylcysteine synthetase. Interactions of an essential sulfhydryl group

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25353619

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1089/ARS.2014.6025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

release_hmilk7xvmjgnhoem2d3atqbz6u

7 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hmilk7xvmjgnhoem2d3atqbz6u

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25353619%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

25353619

1 reference