Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways (Q36313178)

13 August 2017

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title

Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways (English)

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13 August 2017

Lionel Larue

1

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PubMed ID

16288291

13 August 2017

Alfonso Bellacosa

series ordinal

2

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PubMed ID

16288291

13 August 2017

language of work or name

English

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publication date

1 November 2005

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13 August 2017

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13 August 2017

24

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13 August 2017

7443-7454

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13 August 2017

50

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209091

13 August 2017

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Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin

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Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease

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Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

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Dissemination and growth of cancer cells in metastatic sites

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

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Integrin-linked kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition

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Akt-regulated pathways in prostate cancer

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IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition

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IGF-II promotes mesoderm formation

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Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

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The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer.

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Modulation of trophoblast cell death by oxygen and EGF.

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

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EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways.

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M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6

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7 January 2021

Oncogenic mutations of PIK3CA in human cancers

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7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

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7 January 2021

Role of Ets transcription factors in mammary gland development and oncogenesis

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7 January 2021

Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.

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7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

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7 January 2021

Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

AKT plays a central role in tumorigenesis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

AKT signaling in normal and malignant cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Epithelial-mesenchymal transitions in tumour progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Cell adhesion in development: a complex signaling network

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Breast cancer progression with a Twist

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Molecular identification of a putative human hyaluronan synthase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Cancer. Addiction to oncogenes--the Achilles heal of cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Signal transduction: signaling specificity- a complex affair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Nonsense and frameshift mutations in ZFHX1B, encoding Smad-interacting protein 1, cause a complex developmental disorder with a great variety of clinical features

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Wnt-dependent regulation of the E-cadherin repressor snail

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209091

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209091

1 reference

13 August 2017

1 reference

PubMed ID

16288291