Akt-regulated pathways in prostate cancer (Q36313185)

13 August 2017

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title

Akt-regulated pathways in prostate cancer (English)

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13 August 2017

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Pradip K Majumder

1

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PubMed ID

16288293

13 August 2017

William R Sellers

series ordinal

2

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PubMed ID

16288293

13 August 2017

language of work or name

English

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publication date

1 November 2005

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13 August 2017

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13 August 2017

24

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13 August 2017

7465-7474

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13 August 2017

50

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209096

13 August 2017

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cites work

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Design of peptidomimetics that inhibit the association of phosphatidylinositol 3-kinase with platelet-derived growth factor-beta receptor and possess cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

A genome screen of families with multiple cases of prostate cancer: evidence of genetic heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

A novel founder mutation in the RNASEL gene, 471delAAAG, is associated with prostate cancer in Ashkenazi Jews

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Does the ribosome translate cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Novel 2'-substituted, 3'-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Pten dose dictates cancer progression in the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

Amplification of 19q13.1–q13.2 sequences in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

mTOR as a Positive Regulator of Tumor Cell Responses to Hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

The PIK3CA gene is mutated with high frequency in human breast cancers.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Mutation of the PIK3CA gene in ovarian and breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Cancer statistics, 2005

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Germline mutations in PTEN are present in Bannayan-Zonana syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Therapeutic potential of phosphoinositide 3-kinase inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209096

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209096

1 reference

13 August 2017

1 reference

PubMed ID

16288293