p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. (Q36325930)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942597%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint (English)

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9 January 2020

0 references

3

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9 January 2020

author name string

Ande Satyanarayana

series ordinal

1

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9 January 2020

Mary Beth Hilton

series ordinal

2

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9 January 2020

publication date

17 October 2007

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Molecular Biology of the Cell

9 January 2020

published in

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9 January 2020

volume

19

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9 January 2020

issue

1

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9 January 2020

page(s)

65-77

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Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.

9 January 2020

cites work

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A concise review of DNA damage checkpoints and repair in mammalian cells

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Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers

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Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage.

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Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

30 September 2017

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

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The p53 protein family and radiation sensitivity: Yes or no?

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Cdk2 knockout mice are viable

30 September 2017

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Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells

30 September 2017

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MDC1 is a mediator of the mammalian DNA damage checkpoint

30 September 2017

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ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation

30 September 2017

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Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III

30 September 2017

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Genomic instability in mice lacking histone H2AX

30 September 2017

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Liver regeneration after hepatectomy.

30 September 2017

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p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

30 September 2017

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30 September 2017

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ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

30 September 2017

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

30 September 2017

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All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners

30 September 2017

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30 September 2017

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30 September 2017

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Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

30 September 2017

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

30 September 2017

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Nuclear localization of cyclin B1 controls mitotic entry after DNA damage

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors

30 September 2017

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30 September 2017

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Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage

30 September 2017

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30 September 2017

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Mitotic forces control a cell-cycle checkpoint

30 September 2017

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Dominant mutants identify new roles for p34cdc2 in mitosis.

30 September 2017

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30 September 2017

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

30 September 2017

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Cell cycle checkpoints and DNA repair preserve the stability of the human genome

30 September 2017

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Radiation-induced cell cycle arrest compromised by p21 deficiency

30 September 2017

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Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase

30 September 2017

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A simple technique for quantitation of low levels of DNA damage in individual cells

30 September 2017

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p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase

30 September 2017

1 reference

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Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome

30 September 2017

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p53 and ATM: cell cycle, cell death, and cancer.

30 September 2017

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Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase

30 September 2017

1 reference

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Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

30 September 2017

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Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.

29 June 2018

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Control of pRB phosphorylation

29 June 2018

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Cell-cycle signaling: Atm displays its many talents

29 June 2018

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A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay

29 June 2018

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The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

29 June 2018

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Cdc2-cyclin E complexes regulate the G1/S phase transition

29 June 2018

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Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).

22 September 2018

1 reference

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G2 damage checkpoints: what is the turn-on?

22 September 2018

1 reference

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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174178

Proliferation of cancer cells despite CDK2 inhibition.

22 September 2018

1 reference

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Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities.

22 September 2018

1 reference

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Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation

22 September 2018

1 reference

12 December 2020

Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage

1 reference

12 December 2020

Regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1/Sdi1) gene expression in hepatic regeneration

1 reference

12 December 2020

Role of p21(Waf-1) in regulating the G1 and G2/M checkpoints in ultraviolet-irradiated keratinocytes

1 reference

12 December 2020

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1 reference

12 December 2020

Checking on the cell cycle

1 reference

12 December 2020

Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice

1 reference

12 December 2020

Identifiers

DOI

10.1091/MBC.E07-06-0525

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942597%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942597%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

17942597

1 reference