Experimental mechanisms of diabetic embryopathy and strategies for developing therapeutic interventions (Q36330216)

13 August 2017

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title

Experimental mechanisms of diabetic embryopathy and strategies for developing therapeutic interventions (English)

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13 August 2017

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2

E Albert Reece

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13 August 2017

Zhiyong Zhao

1

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13 August 2017

1 December 2005

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13 August 2017

Reproductive Sciences

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13 August 2017

12

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13 August 2017

8

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13 August 2017

549-557

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Congenital malformations in offspring of diabetic mothers--animal and human studies

13 August 2017

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Malformations in infants of diabetic mothers occur before the seventh gestational week. Implications for treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Malformations in infants of diabetic mothers

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Pathogenesis of diabetes-induced congenital malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Diabetes and preimplantation events of embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Hyperglycemia and apoptosis: mechanisms for congenital malformations and pregnancy loss in diabetic women

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Maternal fuels, diabetic embryopathy: pathomechanisms and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

The pathogenesis of diabetes-associated congenital malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Genotoxicity and diabetic embryopathy: impaired expression of developmental control genes as a cause of defective morphogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Free radicals and birth defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

The role of reactive oxygen species in diabetes-induced anomalies in embryos of Cohen diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Early neonatal events and the disease incidence in nonobese diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Effect of diabetes mellitus on mouse pre-implantation embryo development

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Diabetic embryopathy and fuel-mediated organ teratogenesis: lessons from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Genotoxicity of streptozotocin

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Localization of extracellular matrix and mitogen-activated protein kinase (MAPK) in aorta of streptozotocin treated Mongolian gerbils

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Modulation of CFTR chloride channels by calyculin A and genistein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Aberrant patterns of cellular communication in diabetes-induced embryopathy. I. Membrane signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Inhibition of cell proliferation in the embryonic myocardium by A1 adenosine receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Ultrastructural analysis of malformations of the embryonic neural axis induced by in vitro hyperglycemic conditions.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

High glucose concentration inhibits migration of rat cranial neural crest cells in vitro

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Renal development in high-glucose ambience and diabetic embryopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Maturation of fetal rat lung in diabetic pregnancies of graduated severity.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Apoptosis in embryos of diabetic rats.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Hyperglycemia-induced apoptotic cell death in the mouse blastocyst is dependent on expression of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

The Bcl-2 family: roles in cell survival and oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Identification of caspase-6 in rat blastocysts and its implication in the induction of apoptosis by high glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Increased TNF-alpha expression in cultured mouse embryos exposed to teratogenic concentrations of glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Cellular-tissue localization and regulation of the GLUT-1 protein in both the embryo and the visceral yolk sac from normal and experimental diabetic rats during the early postimplantation period.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Pax genes and organogenesis.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Development, morphology, and function of the yolk-sac placenta of laboratory rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Role of the mouse visceral yolk sac in nutrition: inhibition by a somatomedin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Aberrant patterns of cellular communication in diabetes-induced embryopathy in rats: II, apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Glutathione status in diabetes-induced embryopathies.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Dietary vitamin E prophylaxis and diabetic embryopathy: morphologic and biochemical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Effect of different doses of vitamin E on the incidence of malformations in pregnant diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Mitochondria, oxygen free radicals, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Maternal antioxidant treatments prevent diabetes-induced alterations of mitochondrial morphology in rat embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

21 January 2018

Cyclooxygenase-2 Biology

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

The isoprostanes: their quantification as an index of oxidant stress status in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

PGE2 prevents anomalies induced by hyperglycemia or diabetic serum in mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Lipid metabolism in the embryos of diabetic rats during early organogenesis: modulatory effect of prostaglandin E2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

8-Iso-PGF(2alpha) administration generates dysmorphogenesis and increased lipid peroxidation in rat embryos in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Protein kinase C isozymes and the regulation of diverse cell responses

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Activation mechanisms of protein kinase C: maturation, catalytic activation, and targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Effects of insulin and myo-inositol on embryo growth and development during early organogenesis in streptozocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Myo-inositol and prostaglandins reverse the glucose inhibition of neural tube fusion in cultured mouse embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Protein kinase C and the development of diabetic vascular complications

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Mitogen-activated protein kinase signaling

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Redox signaling and the MAP kinase pathways

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Mitogen-activated protein kinases in apoptosis regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

The true face of JNK activation in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Molecular aspects of lipoic acid in the prevention of diabetes complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Effects of ergothioneine on diabetic embryopathy in pregnant rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis in rat embryos in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

Development of early-onset type 2 diabetes in the young: implications for child bearing

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.JSGI.2005.07.005

10.1016/J.JSGI.2005.07.005

21 January 2018

Identifiers

DOI

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13 August 2017

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PubMed ID

16325743