Modulation of Innate Immune Responses via Covalently Linked TLR Agonists (Q36333881)

13 August 2017

Modulation of Innate Immune Responses via Covalently Linked TLR Agonists (English)

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13 August 2017

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Philip L Felgner

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D Huw Davies

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Aaron P Esser-Kahn

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Emmanuel Y Dotsey

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Janine K Tom

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Hollie Y Wong

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13 August 2017

Lalisa Stutts

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13 August 2017

Troy Moore

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28 October 2015

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439-448

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describes a project that uses

13 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4665084/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides

30 September 2017

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A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells

30 September 2017

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Guiding principles in the design of molecular bioconjugates for vaccine applications

30 September 2017

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Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses

30 September 2017

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A nanoliposome delivery system to synergistically trigger TLR4 AND TLR7

30 September 2017

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Structure-based programming of lymph-node targeting in molecular vaccines

30 September 2017

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Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques

30 September 2017

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Key roles of adjuvants in modern vaccines

30 September 2017

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30 September 2017

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MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

30 September 2017

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Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands

30 September 2017

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The synergy in cytokine production through MyD88-TRIF pathways is co-ordinated with ERK phosphorylation in macrophages.

30 September 2017

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1,3,5-Triazine as a modular scaffold for covalent inhibitors with streamlined target identification

30 September 2017

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Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer

30 September 2017

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Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

30 September 2017

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Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines

30 September 2017

1 reference

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Programming the magnitude and persistence of antibody responses with innate immunity

30 September 2017

1 reference

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Regulation and functions of the IL-10 family of cytokines in inflammation and disease

30 September 2017

1 reference

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Vaccine adjuvants: putting innate immunity to work

30 September 2017

1 reference

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TLR-based immune adjuvants.

30 September 2017

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Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages.

30 September 2017

1 reference

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Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

30 September 2017

1 reference

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Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Generation of bone marrow derived murine dendritic cells for use in 2-photon imaging

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Immunity from smallpox vaccine persists for decades: a longitudinal study

30 September 2017

1 reference

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

The contribution of immunology to the rational design of novel antibacterial vaccines

30 September 2017

1 reference

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Cooperation of Toll-like receptor signals in innate immune defence

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Modulating vaccine responses with dendritic cells and Toll-like receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

A co-evolution perspective of the TNFSF and TNFRSF families in the immune system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Macrophage inflammatory protein-1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Activation of the immune system by bacterial CpG-DNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappaB activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Rational design of small molecules as vaccine adjuvants.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Activation of rabbit TLR9 by different CpG-ODN optimized for mouse and human TLR9.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Are we entering a new age for human vaccine adjuvants?

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

The history of Toll-like receptors - redefining innate immunity.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Targeting TLRs expands the antibody repertoire in response to a malaria vaccine

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665084

Cutting edge: New chimeric NOD2/TLR2 adjuvant drastically increases vaccine immunogenicity

22 September 2018

1 reference

12 December 2020

Toll-like receptor-mediated adjuvanticity and immunomodulation in dendritic cells: Implications for peptide vaccines

1 reference

12 December 2020

Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1

1 reference

12 December 2020

The role of CpG motifs in innate immunity

1 reference

12 December 2020

Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy

1 reference

12 December 2020

TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha

1 reference

12 December 2020

10.1021/ACSCENTSCI.5B00274

Identifiers

DOI

0 references

1 reference

13 August 2017

PubMed publication ID

26640818

1 reference