Key roles of adjuvants in modern vaccines (Q38169040)

30 August 2017

Key roles of adjuvants in modern vaccines (English)

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30 August 2017

3

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30 August 2017

Mark T Orr

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Steven G Reed

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1

object named as

Steven G Reed

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PubMed ID

24309663

30 August 2017

language of work or name

English

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publication date

5 December 2013

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30 August 2017

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30 August 2017

19

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30 August 2017

1597-1608

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30 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nm.3409

30 August 2017

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cites work

CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha: II. Functional analysis

1 reference

12 December 2020

The mechanism of action of MF59 - an innately attractive adjuvant formulation

1 reference

12 December 2020

Aluminium-induced granulomas after inaccurate intradermal hyposensitization injections of aluminium-adsorbed depot preparations

1 reference

12 December 2020

Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells

1 reference

12 December 2020

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I.

1 reference

12 December 2020

A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

1 reference

12 December 2020

Targeting human dendritic cell subsets for improved vaccines

1 reference

12 December 2020

Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis

1 reference

12 December 2020

Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity

1 reference

12 December 2020

Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.

1 reference

12 December 2020

Vaccines with aluminum-containing adjuvants: optimizing vaccine efficacy and thermal stability

1 reference

12 December 2020

Systems biology of vaccination for seasonal influenza in humans

1 reference

12 December 2020

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

1 reference

12 December 2020

MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

1 reference

12 December 2020

Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.

1 reference

12 December 2020

Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist.

1 reference

12 December 2020

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

1 reference

12 December 2020

Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only

1 reference

12 December 2020

Immunopotentiation of the humoral response by liposomes: encapsulation versus covalent linkage

1 reference

12 December 2020

Human Toll-like receptor 4 recognizes host-specific LPS modifications.

1 reference

12 December 2020

Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A.

1 reference

12 December 2020

AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland

1 reference

12 December 2020

Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection

1 reference

12 December 2020

Alum adjuvant: some of the tricks of the oldest adjuvant

1 reference

12 December 2020

First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children

1 reference

12 December 2020

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

1 reference

12 December 2020

Type II NKT cells facilitate Alum-sensing and humoral immunity

1 reference

12 December 2020

Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions.

1 reference

12 December 2020

Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate

1 reference

12 December 2020

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity.

1 reference

12 December 2020

MR1 presents microbial vitamin B metabolites to MAIT cells

1 reference

12 December 2020

Eliciting mucosal immunity

1 reference

12 December 2020

Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response

1 reference

12 December 2020

MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020).

1 reference

12 December 2020

AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity

1 reference

12 December 2020

The potential of 1018 ISS adjuvant in hepatitis B vaccines: HEPLISAV™ review

1 reference

12 December 2020

Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?

1 reference

12 December 2020

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

1 reference

12 December 2020

The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells

1 reference

12 December 2020

Gout-associated uric acid crystals activate the NALP3 inflammasome

1 reference

12 December 2020

Technologies for enhanced efficacy of DNA vaccines

1 reference

12 December 2020

Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.

1 reference

12 December 2020

What the Cell “Sees” in Bionanoscience

1 reference

12 December 2020

Molecular and cellular signatures of human vaccine adjuvants.

1 reference

12 December 2020

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.

1 reference

12 December 2020

Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine.

1 reference

12 December 2020

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

1 reference

12 December 2020

Antibody response to polyhistidine-tagged peptide and protein antigens attached to liposomes via lipid-linked nitrilotriacetic acid in mice

1 reference

12 December 2020

Alum adjuvanticity: unraveling a century old mystery

1 reference

12 December 2020

Selection of an adjuvant for seasonal influenza vaccine in elderly people: modelling immunogenicity from a randomized trial

1 reference

12 December 2020

Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns

1 reference

12 December 2020

A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group

1 reference

12 December 2020

Negatively charged liposomes show potent adjuvant activity when simply admixed with protein antigens

1 reference

12 December 2020

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells

1 reference

12 December 2020

MF59 oil-in-water emulsion in combination with a synthetic TLR4 agonist (E6020) is a potent adjuvant for a combination Meningococcus vaccine

1 reference

12 December 2020

Alum's adjuvant action: grease is the word.

1 reference

12 December 2020

Influenza virosomes as a vaccine adjuvant and carrier system

1 reference

12 December 2020

Targeting TLRs expands the antibody repertoire in response to a malaria vaccine.

1 reference

12 December 2020

Randomized controlled trial of RTS,S/AS02D and RTS,S/AS01E malaria candidate vaccines given according to different schedules in Ghanaian children

1 reference

12 December 2020

The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome.

1 reference

12 December 2020

Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China

1 reference

12 December 2020

Quantitative proteomics analysis of adsorbed plasma proteins classifies nanoparticles with different surface properties and size

1 reference

12 December 2020

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

1 reference

12 December 2020

MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines

1 reference

12 December 2020

Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.

1 reference

12 December 2020

DNA released from dying host cells mediates aluminum adjuvant activity

1 reference

12 December 2020

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity

1 reference

12 December 2020

Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis

1 reference

12 December 2020

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

1 reference

12 December 2020

Pre-existing immunity against vaccine vectors--friend or foe?

1 reference

12 December 2020

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

1 reference

12 December 2020

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

1 reference

12 December 2020

Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen

1 reference

12 December 2020

The effect of micro and nanotopography on endocytosis in drug and gene delivery systems.

1 reference

12 December 2020

Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine.

1 reference

12 December 2020

The importance of adjuvant formulation in the development of a tuberculosis vaccine

1 reference

12 December 2020

Programming the magnitude and persistence of antibody responses with innate immunity

1 reference

12 December 2020

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

1 reference

12 December 2020

Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature

1 reference

12 December 2020

Materials engineering for immunomodulation

1 reference

12 December 2020

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

1 reference

12 December 2020

A comparative study of stress-mediated immunological functions with the adjuvanticity of alum

1 reference

12 December 2020

Mechanism of action of licensed vaccine adjuvants

1 reference

12 December 2020

Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine

1 reference

12 December 2020

Liposomal formulations of synthetic MUC1 peptides: effects of encapsulation versus surface display of peptides on immune responses.

1 reference

12 December 2020

Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro

1 reference

12 December 2020

Implications of narcolepsy link with swine-influenza vaccine

1 reference

12 December 2020

Explorations of clinical trials and pharmacovigilance databases of MF59®-adjuvanted influenza vaccines for associated cases of narcolepsy

1 reference

12 December 2020

Pivotal advance: eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production

1 reference

12 December 2020

Relationship between the size of nanoparticles and their adjuvant activity: data from a study with an improved experimental design

1 reference

12 December 2020

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

1 reference

12 December 2020

A randomized, observer-blinded immunogenicity trial of Cervarix(®) and Gardasil(®) Human Papillomavirus vaccines in 12-15 year old girls

1 reference

12 December 2020

Polymer particle shape independently influences binding and internalization by macrophages

1 reference

12 December 2020

Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR

1 reference

12 December 2020

Vaccine adjuvant activity of 3M-052: an imidazoquinoline designed for local activity without systemic cytokine induction

1 reference

12 December 2020

Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants

1 reference

12 December 2020

Enhancing immunogenicity of a 3'aminomethylnicotine-DT-conjugate anti-nicotine vaccine with CpG adjuvant in mice and non-human primates

1 reference

12 December 2020

Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity

1 reference

12 December 2020

Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination

1 reference

12 December 2020

Use of CpG oligodeoxynucleotides as immune adjuvants

1 reference

12 December 2020

Increased potency of an inactivated trivalent polio vaccine with oil-in-water emulsions

1 reference

12 December 2020

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

1 reference

12 December 2020

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses

1 reference

12 December 2020

Adjuvant effect of cationic liposomes and CpG depends on administration route.

1 reference

12 December 2020

Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis

1 reference

12 December 2020

Towards an understanding of the adjuvant action of aluminium

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12 December 2020

How do adjuvants work? Important considerations for new generation adjuvants

1 reference

12 December 2020

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

1 reference

12 December 2020

Accessing the therapeutic potential of immunostimulatory nucleic acids

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12 December 2020

Optimized subunit vaccine protects against experimental leishmaniasis

1 reference

12 December 2020

MF59 formulated with CpG ODN as a potent adjuvant of recombinant HSP65-MUC1 for inducing anti-MUC1+ tumor immunity in mice.

1 reference

12 December 2020

The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production.

1 reference

12 December 2020

Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland

1 reference

12 December 2020

Immunogenicity and safety of an adjuvanted hepatitis B vaccine in pre-hemodialysis and hemodialysis patients

1 reference

12 December 2020

In vivo studies on the effect of co-encapsulation of CpG DNA and antigen in acid-degradable microparticle vaccines

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12 December 2020

MF59 and Pam3CSK4 Boost Adaptive Responses to Influenza Subunit Vaccine through an IFN Type I-Independent Mechanism of Action

1 reference

12 December 2020

A 2-dose regimen of a recombinant hepatitis B vaccine with the immune stimulant AS04 compared with the standard 3-dose regimen of Engerix-B in healthy young adults

1 reference

12 December 2020

Improved CD4⁺ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial.

1 reference

12 December 2020

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

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12 December 2020

The role of the lymphatic system in vaccine trafficking and immune response

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12 December 2020

Chitosan Microparticles and Nanoparticles as Biocompatible Delivery Vehicles for Peptide and Protein-Based Immunocontraceptive Vaccines

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12 December 2020

Innovations in emulsion technology

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Crossref

https://api.crossref.org/works/10.1038%2FNM.3409

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.3409

1 reference

30 August 2017

1 reference

PubMed ID

24309663