Species-specific antibiotic-ribosome interactions: implications for drug development (Q36334935)

13 August 2017

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title

Species-specific antibiotic-ribosome interactions: implications for drug development (English)

1 reference

13 August 2017

Paola Fucini

5

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Daniel N. Wilson

object named as

Daniel N Wilson

1

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Frank Schluenzen

1 reference

ORCID Public Data File 2021

author name string

Jörg M Harms

2

1 reference

PubMed ID

16336118

13 August 2017

Knud H Nierhaus

3

1 reference

PubMed ID

16336118

13 August 2017

Frank Schlünzen

4

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13 August 2017

1 December 2005

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13 August 2017

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13 August 2017

386

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13 August 2017

1239-1252

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13 August 2017

12

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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

13 August 2017

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Overcoming bacterial resistance by dual target inhibition: the case of streptogramins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Crystal structure of an initiation factor bound to the 30S ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

In vitro selection of resistance in Haemophilus influenzae by amoxicillin-clavulanate, cefpodoxime, cefprozil, azithromycin, and clarithromycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Inhibition of protein synthesis by streptogramins and related antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Interaction of the antibiotics clindamycin and lincomycin with Escherichia coli 23S ribosomal RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Macrolide resistance from the ribosome perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

The structures of four macrolide antibiotics bound to the large ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

High resolution structure of the large ribosomal subunit from a mesophilic eubacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

The chemistry of protein synthesis and voyage through the ribosomal tunnel

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Recognition of cognate transfer RNA by the 30S ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

In vivo efficacy of telithromycin (HMR3647) against Streptococcus pneumoniae and Haemophilus influenzae

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Lasting damage to bacterial ribosomes by reversibly bound virginiamycin M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Structural basis for the antibiotic activity of ketolides and azalides

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Peptide derivatives of antibiotics tylosin and desmycosin, protein synthesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Regulatory nascent peptides in the ribosomal tunnel

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Chemical probing of a virginiamycin M-promoted conformational change of the peptidyl-transferase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Lincomycin and clindamycin conformations. A fragment shared by macrolides, ketolides and lincosamides determined from TRNOE ribosome-bound conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Structure of the 30S ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2005.141

21 January 2018

Identifiers

DOI

10.1515/BC.2005.141

1 reference

13 August 2017

1 reference

PubMed ID

16336118