Anti-inflammatory effects of statins: clinical evidence and basic mechanisms (Q36337932)

13 August 2017

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title

Anti-inflammatory effects of statins: clinical evidence and basic mechanisms (English)

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13 August 2017

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Paul M Ridker

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13 August 2017

Mukesh K Jain

1

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13 August 2017

1 December 2005

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Nature Reviews Drug Discovery

13 August 2017

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13 August 2017

4

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13 August 2017

12

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13 August 2017

977-987

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https://scigraph.springernature.com/pub.10.1038/nrd1901

13 August 2017

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21 January 2018

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21 January 2018

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Statins exert endothelial atheroprotective effects via the KLF2 transcription factor

21 January 2018

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21 January 2018

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Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I

21 January 2018

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21 January 2018

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Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Nitric oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemia

31 March 2020

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Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium

31 March 2020

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Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans

31 March 2020

1 reference

Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month

31 March 2020

1 reference

HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis

31 March 2020

1 reference

Inhibition of monocyte chemotactic protein-1 synthesis by statins

31 March 2020

1 reference

HMG-CoA Reductase Inhibitors Decrease CD11b Expression and CD11b-Dependent Adhesion of Monocytes to Endothelium and Reduce Increased Adhesiveness of Monocytes Isolated From Patients With Hypercholesterolemia

31 March 2020

1 reference

Statins for Atherosclerosis — As Good as It Gets?

31 March 2020

1 reference

3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)

31 March 2020

1 reference

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture

31 March 2020

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Platelet activation in unstable coronary disease

31 March 2020

1 reference

Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s)

31 March 2020

1 reference

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

31 March 2020

1 reference

Short-term atorvastatin treatment improves endothelial function in hypercholesterolemic women

31 March 2020

1 reference

HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basal NO and decreasing superoxide

31 March 2020

1 reference

Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors

31 March 2020

1 reference

Peroxisome proliferator-activated receptors as therapeutic targets in inflammation

31 March 2020

1 reference

LKLF: A transcriptional regulator of single-positive T cell quiescence and survival

31 March 2020

1 reference

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1901

1 reference

13 August 2017

1 reference

PubMed ID

16341063