Pharmacogenomics: a path to predictive medicine for schizophrenia (Q36341739)

13 August 2017

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title

Pharmacogenomics: a path to predictive medicine for schizophrenia (English)

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13 August 2017

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4

Ritushree Kukreti

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13 August 2017

Simone Gupta

1

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PubMed ID

16354123

13 August 2017

Sanjeev Jain

series ordinal

2

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PubMed ID

16354123

13 August 2017

Samir K Brahmachari

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3

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13 August 2017

1 January 2006

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13 August 2017

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13 August 2017

7

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13 August 2017

1

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13 August 2017

31-47

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Schizophrenia: diverse approaches to a complex disease

13 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

The discovery of susceptibility genes for mental disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenomics and schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Serotonin receptors: their key role in drugs to treat schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

High-density single-nucleotide polymorphism maps of the human genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenetics of Drug Metabolising Enzymes: Importance for Personalised Medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Metabolism of clozapine by rat brain: the role of flavin-containing monooxygenase (FMO) and cytochrome P450 enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Genes and the response to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Cytochrome P-450 2D6*10 C188T polymorphism is associated with antipsychotic-induced persistent tardive dyskinesia in Chinese schizophrenic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Cytochrome P4502D6 genotype does not determine response to clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Quantitative pharmacogenetics of nortriptyline: a novel approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Functional analysis of the human D2 dopamine receptor missense variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association of the Ser9Gly polymorphism in the dopamine D3 receptor gene with tardive dyskinesia in Korean schizophrenics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Dopamine D3 receptor Ser9Gly polymorphism and risperidone response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

DRD4 exon III polymorphism and response to risperidone in Israeli adolescents with schizophrenia: a pilot pharmacogenetic study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Polymorphisms of the dopamine D4 receptor and response to antipsychotic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenetics as a tool in the therapy of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Serotonin 6 receptor polymorphism in schizophrenia: frequency, age at onset and cognitive function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenetics of tardive dyskinesia: combined analysis of 780 patients supports association with dopamine D3 receptor gene Ser9Gly polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenetics of antipsychotic-induced weight gain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Glutamate and depression: clinical and preclinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

The neurobiology of slow synaptic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Diverse psychotomimetics act through a common signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Functional plasticity in the organization of signaling complexes in the striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Regulation of AMPA receptor dephosphorylation by glutamate receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Ionotropic glutamate receptor modulation of 5-HT6 and 5-HT7 mRNA expression in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

AMPA receptors modulate extracellular 5-hydroxytryptamine concentration and metabolism in rat striatum in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Different activation of NF-kappaB by stimulation of dopamine D2L and D2S receptors through calcineurin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Serotonin and brain development.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Subunit- and site-specific pharmacology of the NMDA receptor channel

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Modulation of N-methyl-D-aspartate receptor function by glycine transport

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

In search of susceptibility genes for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Proline-induced potentiation of glutamate transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

The gene encoding proline dehydrogenase modulates sensorimotor gating in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Facilitated NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 area of dystrophin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Ionotropic and metabotropic glutamate receptor structure and pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Regulation of neurotransmitter release by metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Molecular determinants of metabotropic glutamate receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

GABAB receptor agonists and antagonists: pharmacological properties and therapeutic possibilities.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

GABA-glutamate interaction in the control of BDNF expression in hypothalamic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

An association study of dopamine receptors polymorphisms and the Wisconsin Card Sorting Test in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association between dopamine receptor D1 gene DdeI polymorphism and sensation seeking in alcohol-dependent men.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

A48G polymorphism in the D1 receptor genes associated with bipolar I disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association study of 90 candidate gene polymorphisms in panic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenetics of dopamine receptors and response to antipsychotic drugs in schizophrenia--an update

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Effects of dopamine D2 receptor (DRD2) and transporter (SLC6A3) polymorphisms on smoking cue-induced cigarette craving among African-American smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

The influence on the schizophrenic symptoms by the DRD2Ser/Cys311 and -141C Ins/Del polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenetic studies of response to risperidone and other newer atypical antipsychotics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

First- and second-generation antipsychotic medication and cognitive processing in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associations with cognitive and motor impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association of aggressive behavior in Korean male schizophrenic patients with polymorphisms in the serotonin transporter promoter and catecholamine-O-methyltransferase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processing

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Negative symptoms of schizophrenia could explain discrepant data on the association between the 5-HT2A receptor gene and response to antipsychotics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association between schizophrenia and DRD3 or HTR2 receptor gene variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association study of neuregulin 1 gene with schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Support for RGS4 as a susceptibility gene for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association of DAAO with schizophrenia in the Chinese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

BDNF gene is a risk factor for schizophrenia in a Scottish population.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Possible association between the gamma-aminobutyric acid type B receptor 1 (GABBR1) gene and schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association of SNPs and haplotypes in GABAA receptor beta2 gene with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Hypothesis: minimal changes in neural transmission in schizophrenia: decreased glutamatergic and GABAergic functions in the prefrontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Functional consequences of PRODH missense mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

PRODH mutations and hyperprolinemia in a subset of schizophrenic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Glutamate transporters as drug targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

DARPP-32: regulator of the efficacy of dopaminergic neurotransmission

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenetics of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Application of pharmacogenetics to psychotic disorders: the first consensus conference. The Consensus Group for Outcome Measures in Psychoses for Pharmacological Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenomics: translating functional genomics into rational therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Tardive dyskinesia and DRD2, DRD3, DRD4, 5-HT2A variants in schizophrenia: an association study with repeated assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Association between three functional polymorphisms of the dopamine D2 receptor gene and polydipsia in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

Pharmacogenetic prediction of clozapine response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.1.31

21 January 2018

Identifiers

DOI

10.2217/14622416.7.1.31

1 reference

13 August 2017

1 reference

PubMed ID

16354123