Mechanisms of genotoxicity of nucleoside reverse transcriptase inhibitors (Q36361723)

13 August 2017

title

Mechanisms of genotoxicity of nucleoside reverse transcriptase inhibitors (English)

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13 August 2017

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1

Ofelia A Olivero

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13 August 2017

publication date

1 April 2007

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Environmental and Molecular Mutagenesis

13 August 2017

published in

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13 August 2017

volume

48

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13 August 2017

issue

3-4

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13 August 2017

page(s)

215-223

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Induction of the SOS response in Escherichia coli by azidothymidine and dideoxynucleosides

13 August 2017

cites work

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3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

21 January 2018

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Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

21 January 2018

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Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT

21 January 2018

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Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3'-azido-2',3'-dideoxythymidine

21 January 2018

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7 January 2021

Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase

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7 January 2021

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

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7 January 2021

Biochemical pharmacology of zidovudine in human T-lymphoblastoid cells (CEM).

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7 January 2021

Oxidative DNA damage in fetal tissues after transplacental exposure to 3'-azido-3'-deoxythymidine (AZT)

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7 January 2021

Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage

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7 January 2021

Synchronization of cells in the S phase of the cell cycle by 3'-azido-3'-deoxythymidine: implications for cell cytotoxicity

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7 January 2021

Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group

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7 January 2021

Mitochondrial myopathy caused by long-term zidovudine therapy

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7 January 2021

3'-Azido-3'-deoxythymidine cytotoxicity and metabolism in the human colon tumor cell line HCT-8.

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7 January 2021

AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins

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7 January 2021

Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver

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7 January 2021

Induction of micronuclei by low doses of azidothymidine (AZT)

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7 January 2021

Azidothymidine induces apoptosis and inhibits cell growth and telomerase activity of human parathyroid cancer cells in culture.

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7 January 2021

Development of a novel 32P-postlabeling method for the analysis of 3′-azido-3′-deoxythymidine

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7 January 2021

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

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7 January 2021

Irreversible telomere shortening by 3'-azido-2',3'-dideoxythymidine (AZT) treatment

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7 January 2021

Genotoxic activity of azidothymidine (AZT) in in vitro systems

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7 January 2021

2', 3'-Dideoxycytidine represses thymidine kinases 1 and 2 expression in T-lymphoid cells

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7 January 2021

Inhibition of immune functions by antiviral drugs

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7 January 2021

Decreased thymidine kinase levels in peripheral blood cells from HIV-seropositive individuals: implications for zidovudine metabolism.

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7 January 2021

Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase

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7 January 2021

Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine

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7 January 2021

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

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7 January 2021

Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

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7 January 2021

Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

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7 January 2021

Zidovudine-didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells

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7 January 2021

Molecular analysis of mutations at the HPRT and TK loci of human lymphoblastoid cells after combined treatments with 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosinedagger

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7 January 2021

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro

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7 January 2021

Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines

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7 January 2021

AZT incorporation into mitochondria: study in a human myeloid cell line

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7 January 2021

Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance

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7 January 2021

Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys

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7 January 2021

Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero

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7 January 2021

Plasma drug levels compared with DNA incorporation of 3'-azido-3'-deoxythymidine (AZT) in adult cynomolgus (Macaca fascicularis) monkeys.

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7 January 2021

Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells

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7 January 2021

Elective cesarean delivery plus short-course lamivudine and zidovudine for the prevention of mother-to-child transmission of human immunodeficiency virus type 1.

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7 January 2021

Induction of micronuclei in mouse bone marrow cells: an evaluation of nucleoside analogues used in the treatment of AIDS.

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7 January 2021

Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs

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7 January 2021

Combination studies with 3'-azido-3'-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects

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7 January 2021

The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

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7 January 2021

Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs

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7 January 2021

Quantitative analysis of 3'-azido-3'-deoxythymidine incorporation into DNA in human colon tumor cells

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7 January 2021

Removal of anti-human immunodeficiency virus 2',3'-dideoxynucleoside monophosphates from DNA by a novel human cytosolic 3'-->5' exonuclease

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7 January 2021

AZT-induction of micronuclei in human lymphocyte subpopulations

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7 January 2021

The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena

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7 January 2021

Hydroxyurea enhances 3'-azido-3'-deoxythymidine (AZT) cytotoxicity in human chronic myeloid leukemia models

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7 January 2021

Lack of reduction of thymidine kinase activity in stavudine-treated HIV-infected patients

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7 January 2021

Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs

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7 January 2021

Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment

1 reference

7 January 2021

Synthesis, in vitro anticancer evaluation, and interference with cell cycle progression of N-phosphoamino acid esters of zidovudine and stavudine.

1 reference

7 January 2021

Identifiers

DOI

10.1002/EM.20195

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13 August 2017

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