Coordinate transcriptional regulation of transport and metabolism (Q36363120)

13 August 2017

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title

Coordinate transcriptional regulation of transport and metabolism (English)

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13 August 2017

Jyrki J Eloranta

1

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13 August 2017

Peter J Meier

series ordinal

2

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13 August 2017

Gerd A Kullak-Ublick

series ordinal

3

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13 August 2017

language of work or name

English

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publication date

1 January 2005

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13 August 2017

Methods in Enzymology

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13 August 2017

400

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13 August 2017

511-530

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Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

13 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Orphan nuclear receptors--new ligands and new possibilities.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Liver-enriched transcription factors and hepatocyte differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12alpha -hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Identification of a nuclear receptor that is activated by farnesol metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

DNA binding and transcription activation specificity of hepatocyte nuclear factor 4

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

HNF-4alpha: from MODY to late-onset type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Induction of drug metabolism: the role of nuclear receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Nuclear-receptor interactions on DNA-response elements

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Enterohepatic bile salt transporters in normal physiology and liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The structure of the nuclear hormone receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Identification of a nuclear receptor for bile acids

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Bile salt transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Clinical importance of the cytochromes P450

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Bile acid-induced negative feedback regulation of the human ileal bile acid transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Functional expression of the canalicular bile salt export pump of human liver

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Bile acids: natural ligands for an orphan nuclear receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Acute heart transplant rejection due to Saint John's wort

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The multispecific organic anion transporter (OAT) family.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Role of protein methylation in chromatin remodeling and transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Acetylation of histones and transcription-related factors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Sulfonation and molecular action

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Bile salt transporters: molecular characterization, function, and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Redundant pathways for negative feedback regulation of bile acid production

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

On the mechanism of bile acid inhibition of rat sterol 12α-hydroxylase gene (CYP8B1) transcription: roles of α-fetoprotein transcription factor and hepatocyte nuclear factor 4α

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

Suppression of sterol 12alpha-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2900028-5

7 January 2021

10.1016/S0076-6879(05)00028-5

Identifiers

DOI

1 reference

13 August 2017

1 reference