Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax. (Q36368546)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

title

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax (English)

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2 November 2019

6

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2 November 2019

author name string

J A Heibein

1

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2 November 2019

I S Goping

2

1 reference

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2 November 2019

M Barry

3

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2 November 2019

M J Pinkoski

4

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2 November 2019

G C Shore

5

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2 November 2019

R C Bleackley

7

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2 November 2019

language of work or name

English

0 references

publication date

1 November 2000

1 reference

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Journal of Experimental Medicine

2 November 2019

published in

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2 November 2019

volume

192

1 reference

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2 November 2019

issue

10

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2 November 2019

page(s)

1391-1402

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

2 November 2019

cites work

1 reference

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

28 June 2018

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Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation.

28 June 2018

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Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells.

28 June 2018

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Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

28 June 2018

1 reference

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

28 June 2018

1 reference

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Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

28 June 2018

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Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent

28 June 2018

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Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.

28 June 2018

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

28 June 2018

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Conformation of the Bax C-terminus regulates subcellular location and cell death

28 June 2018

1 reference

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Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells

28 June 2018

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Emerging roles of caspase-3 in apoptosis

28 June 2018

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Investigation of bax-induced release of cytochrome c from yeast mitochondria permeability of mitochondrial membranes, role of VDAC and ATP requirement

28 June 2018

1 reference

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Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

28 June 2018

1 reference

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Solution structure of BID, an intracellular amplifier of apoptotic signaling

28 June 2018

1 reference

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

28 June 2018

1 reference

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

28 June 2018

1 reference

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Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Definition and redesign of the extended substrate specificity of granzyme B.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Regulated targeting of BAX to mitochondria.

28 June 2018

1 reference

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Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

28 June 2018

1 reference

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28 June 2018

Caspases: enemies within

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Bax directly induces release of cytochrome c from isolated mitochondria

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Movement of Bax from the cytosol to mitochondria during apoptosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

28 June 2018

1 reference

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Caspases: killer proteases

28 June 2018

1 reference

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

BID: a novel BH3 domain-only death agonist

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Mechanisms of lysis by cytotoxic T cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

28 June 2018

1 reference

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Processing and activation of CMH-1 by granzyme B.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Bax membrane insertion during Fas(CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193181

Cleavage of caspase family members by granzyme B: a comparative study in vitro.

21 September 2018

1 reference

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Two CD95 (APO-1/Fas) signaling pathways

21 September 2018

1 reference

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Gene targeting studies begin to reveal the function of neurofilament proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.192.10.1391

How do cytotoxic lymphocytes kill their targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.192.10.1391

The energetic afterglow of the γ-ray burst of 14 December 1997

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.192.10.1391

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.192.10.1391

Electrostatic reversal of serine proteinase substrate specificity

21 January 2018

1 reference

12 December 2020

BID-dependent and BID-independent pathways for BAX insertion into mitochondria

1 reference

12 December 2020

The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition

1 reference

12 December 2020

Death by a thousand cuts: an ever increasing list of caspase substrates

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.192.10.1391

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085742%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

PubMed publication ID

11085742

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085742%20AND%20SRC:MED&resulttype=core&format=json