The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA). (Q36392365)

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English	The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA).	scientific article

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8 March 2020

The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA) (English)

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8 March 2020

methicillin-resistant Staphylococcus aureus

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Staphylococcus aureus

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based on heuristic

inferred from title

3

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8 March 2020

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Mayland Chang

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8 March 2020

Shahriar Mobashery

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Shahriar Mobashery

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Jennifer Fishovitz

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8 March 2020

Negin Taghizadeh

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18 May 2015

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8 March 2020

Journal of the American Chemical Society

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8 March 2020

6500-6505

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8 March 2020

Missense mutations in PBP2A Affecting ceftaroline susceptibility detected in epidemic hospital-acquired methicillin-resistant Staphylococcus aureus clonotypes ST228 and ST247 in Western Switzerland archived since 1998

1 reference

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30 September 2017

PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates.

1 reference

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Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

1 reference

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Neutral β-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA.

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The emergence of mecC methicillin-resistant Staphylococcus aureus

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How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

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Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics

1 reference

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30 September 2017

Allostery in disease and in drug discovery

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Systems-level antimicrobial drug and drug synergy discovery

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Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions

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Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall.

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30 September 2017

Distinct single-cell morphological dynamics under beta-lactam antibiotics

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Structural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole

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30 September 2017

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics

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30 September 2017

Identification of genetic determinants and enzymes involved with the amidation of glutamic acid residues in the peptidoglycan of Staphylococcus aureus

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30 September 2017

Peptidoglycan turnover and recycling in Gram-positive bacteria

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Ceftaroline: a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus

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Ceftaroline: a comprehensive update

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30 September 2017

Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.

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30 September 2017

Frameworks for understanding long-range intra-protein communication

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30 September 2017

Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains

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30 September 2017

Allosteric regulation and catalysis emerge via a common route.

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30 September 2017

Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics

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Allostery and cooperativity revisited

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Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power

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Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus

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The carboxyl terminus of peptidoglycan stem peptides is a determinant for methicillin resistance in Staphylococcus aureus

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An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci

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Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine

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Transition state structures of a dipeptide related to the mode of action of beta-lactam antibiotics

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Properties of a novel PBP2A protein homolog from Staphylococcus aureus strain LGA251 and its contribution to the β-lactam-resistant phenotype.

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Conformation of penicillin as a transition-state analog of the substrate of peptidoglycan transpeptidase.

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Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

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12 December 2020

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10.1021/JACS.5B01374

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8 March 2020

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8 March 2020

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8 March 2020

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