An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishment (Q36397627)

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English	An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishment	scientific article

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13 February 2020

An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishment (English)

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13 February 2020

human papillomavirus 16

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human papilloma virus

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human papillomavirus

29 September 2024

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Mary M Donaldson

1

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13 February 2020

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13 February 2020

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Lorna J Mackintosh

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13 February 2020

Edward S Dornan

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13 February 2020

Laimonis A Laimins

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13 February 2020

Iain M Morgan

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13 February 2020

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12 September 2012

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13 February 2020

Journal of Virology

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13 February 2020

86

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13 February 2020

23

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13 February 2020

12806-12815

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13 February 2020

describes a project that uses

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11 June 2022

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TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

BRCT domains: easy as one, two, three

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

The E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

In vivo analysis of the cell cycle dependent association of the bovine papillomavirus E2 protein and ChlR1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Human papillomavirus 16 E2 stability and transcriptional activation is enhanced by E1 via a direct protein-protein interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

hSNF5 Is Required for Human Papillomavirus E2-Driven Transcriptional Activation and DNA Replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Human papillomavirus oncoproteins: pathways to transformation

1 reference

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30 September 2017

Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Treslin collaborates with TopBP1 in triggering the initiation of DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

1 reference

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30 September 2017

Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM

1 reference

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30 September 2017

Papillomaviruses in the causation of human cancers - a brief historical account

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

TopBP1 regulates human papillomavirus type 16 E2 interaction with chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

TopBP1 activates the ATR-ATRIP complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

The role of human papillomavirus in squamous carcinoma of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Variations in the association of papillomavirus E2 proteins with mitotic chromosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Human TopBP1 ensures genome integrity during normal S phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Genetic analysis of the human papillomavirus type 31 differentiation-dependent late promoter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Analysis of chromatin attachment and partitioning functions of bovine papillomavirus type 1 E2 protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

A novel technique with enhanced detection and quantitation of HPV-16 E1- and E2-mediated DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Regulation of E2F1 by BRCT Domain-Containing Protein TopBP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

BRCT domain-containing protein TopBP1 functions in DNA replication and damage response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

A novel silencer element in the bovine papillomavirus type 4 promoter represses the transcriptional response to papillomavirus E2 protein

1 reference

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30 September 2017

AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Interaction of the papillomavirus E2 protein with mitotic chromosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Structure of the intact transactivation domain of the human papillomavirus E2 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Human papillomavirus type 31b E1 and E2 transcript expression correlates with vegetative viral genome amplification

1 reference

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30 September 2017

A C-terminal helicase domain of the human papillomavirus E1 protein binds E2 and the DNA polymerase alpha-primase p68 subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

The papillomavirus E1 protein forms a DNA-dependent hexameric complex with ATPase and DNA helicase activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Activation of papillomavirus late gene transcription and genome amplification upon differentiation in semisolid medium is coincident with expression of involucrin and transglutaminase but not keratin-10.

1 reference

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30 September 2017

Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

In vitro systems for the study and propagation of human papillomaviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes.

1 reference

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30 September 2017

Amino-terminal domains of the bovine papillomavirus type 1 E1 and E2 proteins participate in complex formation

1 reference

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30 September 2017

The interaction between human papillomavirus type 16 E1 and E2 proteins is blocked by an antibody to the N-terminal region of E2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Cellular factors required for papillomavirus DNA replication.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes.

1 reference

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30 September 2017

The viral transcriptional regulatory region upstream of the E6 and E7 genes is a major determinant of the differential immortalization activities of human papillomavirus types 16 and 18

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

30 September 2017

Human TopBP1 localization to the mitotic centrosome mediates mitotic progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

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Variable expression of some "housekeeping" genes during human keratinocyte differentiation

1 reference

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28 June 2018

Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator

1 reference

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28 June 2018

Functional analysis of E2-mediated repression of the HPV18 P105 promoter

1 reference

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28 June 2018

GEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication

1 reference

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21 September 2018

Tax1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability

1 reference

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21 September 2018

TopBP1 associates with NBS1 and is involved in homologous recombination repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

21 September 2018

Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

1 reference

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21 September 2018

An acidic amphipathic helix in the Bovine Papillomavirus E2 protein is critical for DNA replication and interaction with the E1 protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

21 September 2018

Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction

1 reference

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21 September 2018

Novel cellular interacting partners of the human papillomavirus 16 transcription/replication factor E2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497701

21 September 2018

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10.1128/JVI.01002-12

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Europe PubMed Central

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13 February 2020

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Europe PubMed Central

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13 February 2020

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Europe PubMed Central

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13 February 2020

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