A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication (Q36402679)

14 August 2017

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication (English)

1 reference

Juan Carlos Alvarez Perez

14 August 2017

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Peng Wang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Dan P Felsenfeld

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Hongtao Liu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Sharmila Sivendran

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Aaron Bender

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Anil Kumar

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Roberto Sanchez

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Donald K Scott

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Adolfo Garcia-Ocaña

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Andrew F Stewart

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

language of work or name

English

0 references

publication date

9 March 2015

1 reference

14 August 2017

6

1 reference

inferred from page(s)

published in

Nature Medicine

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

383-388

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

5 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4690535/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nm.3820

0 references

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30 September 2017

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30 September 2017

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ChREBP mediates glucose-stimulated pancreatic β-cell proliferation

30 September 2017

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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells

30 September 2017

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cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication.

30 September 2017

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Activation, regulation, and inhibition of DYRK1A.

30 September 2017

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Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

30 September 2017

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Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

30 September 2017

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The ups and downs of Myc biology

30 September 2017

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Identification of small-molecule inducers of pancreatic beta-cell expansion

30 September 2017

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Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo

30 September 2017

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Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets

30 September 2017

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Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

30 September 2017

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Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function

30 September 2017

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30 September 2017

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

30 September 2017

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Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

30 September 2017

1 reference

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

30 September 2017

1 reference

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30 September 2017

1 reference

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30 September 2017

1 reference

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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

Identification of c-MYC as a target of the APC pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

GABA promotes human β-cell proliferation and modulates glucose homeostasis.

28 June 2018

1 reference

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Mechanism of dual specificity kinase activity of DYRK1A.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

Regulated beta-cell regeneration in the adult mouse pancreas.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4690535

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25751815

12 December 2020

inferred from PubMed ID database lookup

Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25751815

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NM.3820

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25751815%20AND%20SRC:MED&resulttype=core&format=json