Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen. (Q36407213)

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English	Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen.	scientific article

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9 January 2020

Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen (English)

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9 January 2020

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9 January 2020

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Marta Murcia

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9 January 2020

Charles Karan

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9 January 2020

Markéta Jirousková

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9 January 2020

Barry S Coller

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31 October 2007

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9 January 2020

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9 January 2020

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9 January 2020

1248-1256

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9 January 2020

Integrin regulation

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30 September 2017

Probing for integrin alpha v beta3 binding of RGD peptides using fluorescence polarization

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30 September 2017

Immune thrombocytopenia caused by glycoprotein IIb/IIIa inhibitors

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30 September 2017

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

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30 September 2017

Progress in the field of GPIIb/IIIa antagonists

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30 September 2017

Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation

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30 September 2017

Integrins: dynamic scaffolds for adhesion and signaling in platelets

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30 September 2017

Oral GPIIb/IIIa antagonists: what went wrong?

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30 September 2017

Virtual screening with flexible docking and COMBINE-based models. Application to a series of factor Xa inhibitors

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30 September 2017

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

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30 September 2017

Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a meta-analysis of phase III multicenter randomized trials

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30 September 2017

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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30 September 2017

Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease.

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30 September 2017

VMD: visual molecular dynamics

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30 September 2017

Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor

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30 September 2017

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.

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30 September 2017

A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa

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30 September 2017

Platelet-collagen adhesion: inhibition by a monoclonal antibody that binds glycoprotein IIb.

1 reference

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30 September 2017

von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia

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30 September 2017

Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2214768

30 September 2017

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors

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30 September 2017

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

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30 September 2017

GPIIb-IIIa: the responsive integrin

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30 September 2017

Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis

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30 September 2017

Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics.

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28 June 2018

Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit

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28 June 2018

The use of trypsin for the determination of cellular viability.

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28 June 2018

Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins.

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28 June 2018

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

1 reference

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28 June 2018

Conformational modulation of purified glycoprotein (GP) IIb-IIIa allows proteolytic generation of active fragments from either active or inactive GPIIb-IIIa

1 reference

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28 June 2018

Reversible conformational changes induced in glycoprotein IIb-IIIa by a potent and selective peptidomimetic inhibitor

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28 June 2018

Mechanisms involved in the antiplatelet activity of 8-methyl-4-(1-piperazinyl)-7-(3-pyridinylmethoxy)-2H-1-benzopyran-2-one (RC414).

1 reference

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21 September 2018

Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy

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21 September 2018

Coumarin, chromone, and 4(3H)-pyrimidinone novel bicyclic and tricyclic derivatives as antiplatelet agents: synthesis, biological evaluation, and comparative molecular field analysis

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21 September 2018

Platelet glycoprotein IIb/IIIa inhibitors: recognition of a two-edged sword?

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21 September 2018

Cone and plate(let) analyzer: monitoring glycoprotein IIb/IIIa antagonists and von Willebrand disease replacement therapy by testing platelet deposition under flow conditions.

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21 September 2018

Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms

1 reference

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21 September 2018

A conformation-dependent epitope of human platelet glycoprotein IIIa

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of normal, thrombasthenic, and Bernard-Soulier platelets with immobilized fibrinogen: defective platelet-fibrinogen interaction in thrombasthenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrinogen competes with von Willebrand factor for binding to the glycoprotein IIb/IIIa complex when platelets are stimulated with thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition site for the platelet receptor is present on the 15-residue carboxy-terminal fragment of the γ chain of human fibrinogen and is not involved in the fibrin polymerization reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of a ligand induced binding site (LIBS) by GPIIb-IIIa ligand recognition peptides and parenteral antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 2-(1-piperazinyl)-4H-pyrido[1,2-a]pyrimidin-4-one (AP155) on human platelets in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial inhibition of platelet aggregation and fibrinogen binding by a murine monoclonal antibody to GPIIIa: requirement for antibody bivalency

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measuring platelet aggregation with microplate reader. A new technical approach to platelet aggregation studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pentamidine is a specific, non-peptide, GPIIb/IIIa antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The residues AGDV of recombinant gamma chains of human fibrinogen must be carboxy-terminal to support human platelet aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between ligand-induced conformational changes of integrin IIbbeta3 and IIbbeta3-mediated intracellular Ca2+ signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2007-08-105544

1 reference

Europe PubMed Central

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9 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17978171%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

Europe PubMed Central

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9 January 2020

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