Translating genomic biomarkers into clinically useful diagnostics (Q36411676)

14 August 2017

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title

Translating genomic biomarkers into clinically useful diagnostics (English)

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14 August 2017

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Geoffrey S Ginsburg

1

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PubMed ID

16512778

14 August 2017

Susanne B Haga

series ordinal

2

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14 August 2017

1 March 2006

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

14 August 2017

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14 August 2017

6

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14 August 2017

2

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14 August 2017

179-191

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Novel serologic markers of cardiovascular risk

14 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Clinical applications of B-type natriuretic peptide (BNP) testing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

B-type natriuretic peptide as a biomarker beyond heart failure: speculations and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Determination of tumour marker genes from gene expression data

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Cyclin D1 amplification and p16(MTS1/CDK4I) deletion correlate with poor prognosis in head and neck tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Will the new cytogenetics replace the old cytogenetics?

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Identification of four gene variants associated with myocardial infarction

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

The structure of haplotype blocks in the human genome

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

A haplotype map of the human genome

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

21 January 2018

MicroRNAs as oncogenes

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Identification of hundreds of conserved and nonconserved human microRNAs

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

MicroRNA expression profiles classify human cancers

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

A microRNA polycistron as a potential human oncogene

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Promoter methylation profiling of 30 genes in human malignant melanoma.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Gene-promoter hypermethylation as a biomarker in lung cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Emerging molecular markers of cancer.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Protein microarrays as tools for functional proteomics

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Challenges facing the development and use of protein chips to analyze the phosphoproteome

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Peptides in body fluids and tissues as markers of disease

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Peptidomic analysis of human blood specimens: comparison between plasma specimens and serum by differential peptide display

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Use of proteomic patterns in serum to identify ovarian cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Autoantibody signatures in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

The next wave in metabolome analysis

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Metabolomics – the link between genotypes and phenotypes

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Metabolomics in systems biology

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Metabolic profiles of cancer cells

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Metabonomic modeling of drug toxicity

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Metabonomics: a platform for studying drug toxicity and gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Diagnostic genome profiling in mental retardation

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Comparing the genetic changes detected in the primary and secondary tumor sites of ovarian cancer using comparative genomic hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Gene expression profiling predicts clinical outcome of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

A gene-expression signature as a predictor of survival in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Prospects and pitfalls in whole genome association studies

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Whole genome association study of rheumatoid arthritis using 27 039 microsatellites

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Proteomic analysis of human acute leukemia cells: insight into their classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Surfaced-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) differentiation of serum protein profiles of BRCA-1 and sporadic breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Toxicogenomics in the pharmaceutical industry: hollow promises or real benefit?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Large-scale databases in toxicogenomics

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Drug metabolism and variability among patients in drug response

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Pharmacogenetics of the arylamine N-acetyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Identification of novel markers for monitoring minimal residual disease in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Nutritional genomics: the next frontier in the postgenomic era

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Nutrigenomics and nutrigenetics: the emerging faces of nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Advances in clinical cancer proteomics: SELDI-ToF-mass spectrometry and biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Pattern recognition techniques in microarray data analysis: a survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Predicting the clinical status of human breast cancer by using gene expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Empirical bayes methods and false discovery rates for microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

A comprehensive review of genetic association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Replication validity of genetic association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Gene expression profile associated with response to doxorubicin-based therapy in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Serum proteomic fingerprinting discriminates between clinical stages and predicts disease progression in melanoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Validation of genomics-based prognostic tests in malignant pleural mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Tissue microarrays: applications in genomic research

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Molecular basis of ethnic differences in drug disposition and response

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Racial differences in responses to drug treatment: implications for pharmacotherapy of heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

A review and assessment of potential sources of ethnic differences in drug responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Pharmacokinetic-pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Present and future of rapid and/or high-throughput methods for nucleic acid testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Validation of tissue microarray immunohistochemistry staining and interpretation in diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Education: Teaching pharmacogenomics to prepare future physicians and researchers for personalized medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

From pharmacogenetics to personalized medicine: a vital need for educating health professionals and the community

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

American Cancer Society guidelines for breast cancer screening: update 2003.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Economic analyses of human genetics services: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

A systematic review of cost-effectiveness analyses of pharmacogenomic interventions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

The Economic Implications of Noninvasive Molecular Testing for Cardiac Allograft Rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

Reply to 'Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10'

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.6.2.179

21 January 2018

Identifiers

DOI

10.1586/14737159.6.2.179

1 reference

14 August 2017

1 reference

PubMed ID

16512778