Drosophila models pioneer a new approach to drug discovery for Parkinson's disease (Q36419985)

14 August 2017

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title

Drosophila models pioneer a new approach to drug discovery for Parkinson's disease (English)

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14 August 2017

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Paul D Wes

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Alexander J. Whitworth

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Alexander J Whitworth

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1

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author name string

Leo J Pallanck

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3

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14 August 2017

1 February 2006

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14 August 2017

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14 August 2017

11

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14 August 2017

119-126

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14 August 2017

3-4

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Molecular pathogenesis of Parkinson disease

14 August 2017

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Comparative genomics of the eukaryotes

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Alpha-synuclein in Lewy bodies

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

A Drosophila model of Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Pharmacological prevention of Parkinson disease in Drosophila.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Parkin counteracts symptoms in a Drosophila model of Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

alpha-Synuclein is phosphorylated in synucleinopathy lesions

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Remote control of behavior through genetically targeted photostimulation of neurons

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Glutathione transferases

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

DJ-1, a novel regulator of the tumor suppressor PTEN.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

Molecular pathophysiology of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903693-7

7 January 2021

10.1016/S1359-6446(05)03693-7

Identifiers

DOI

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14 August 2017

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PubMed ID

16533709