Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. (Q52655035)

5 May 2018

title

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. (English)

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5 May 2018

author

Alexander J. Whitworth

2

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5 May 2018

author name string

Jessica C Greene

1

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5 May 2018

Laurie A Andrews

3

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5 May 2018

Tracey J Parker

4

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5 May 2018

Leo J Pallanck

5

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5 May 2018

publication date

2 February 2005

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5 May 2018

published in

Human Molecular Genetics

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5 May 2018

volume

14

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5 May 2018

issue

6

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5 May 2018

page(s)

799-811

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5 May 2018

Glutathione, iron and Parkinson's disease

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Association of interleukin-1 beta polymorphisms with idiopathic Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Unraveling the pathogenesis of Parkinson's disease--the contribution of monogenic forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Impact of genetic analysis on Parkinson's disease research

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Parkin mutations are frequent in patients with isolated early-onset parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Genetics of parkin-linked disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Parkin's substrates and the pathways leading to neuronal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

How do Parkin mutations result in neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

The Drosophila melanogaster genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

DAVID: Database for Annotation, Visualization, and Integrated Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Glucose-regulated stress proteins and antibacterial immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

A modular misexpression screen in Drosophila detecting tissue-specific phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Cloning, expression and biochemical characterization of one Epsilon-class (GST-3) and ten Delta-class (GST-1) glutathione S-transferases from Drosophila melanogaster, and identification of additional nine members of the Epsilon class.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Genome wide analysis of common and specific stress responses in adult drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Immunocytochemical analyses and targeted gene disruption of GTPBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Peripheral benzodiazepine receptors and mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Characterization of the origins of astrocyte response to injury using the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Characterization and function of mitochondrial nitric-oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Early and late molecular events in neurodegeneration and neuroprotection in Parkinson's disease MPTP model as assessed by cDNA microarray; the role of iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI074

21 January 2018

Identifiers

DOI

10.1093/HMG/DDI074

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5 May 2018

PubMed ID

15689351

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5 May 2018