HSP90: a rising star on the horizon of anticancer targets (Q36429542)

14 August 2017

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title

HSP90: a rising star on the horizon of anticancer targets (English)

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14 August 2017

2

Luke Whitesell

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14 August 2017

Chengkai Dai

1

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PubMed ID

16556029

14 August 2017

language of work or name

English

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publication date

1 August 2005

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14 August 2017

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14 August 2017

1

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14 August 2017

529-540

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14 August 2017

4

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

14 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Regulation of glucocorticoid receptor steroid binding and trafficking by the hsp90/hsp70-based chaperone machinery: implications for clinical intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Multiple components of the HSP90 chaperone complex function in regulation of heat shock factor 1 In vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Heat shock protein 90-antagonist destabilizes Bcr-Abl/HSP90 chaperone complex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Stable association of hsp90 and p23, but Not hsp70, with active human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Structure and functional relationships of Hsp90.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.529

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.529

A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Expression of hsp90 and cyclin D1 in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Molecular cloning, identification and analysis of lung squamous cell carcinoma-related genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Induction of HSF1 expression is associated with sporadic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

CHIP: a link between the chaperone and proteasome systems

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

ErbB2 degradation mediated by the co-chaperone protein CHIP

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

GHKL, an emergent ATPase/kinase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Development of Radicicol Analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Sequence-dependent enhancement of paclitaxel toxicity in non-small cell lung cancer by 17-allylamino 17-demethoxygeldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

The role of functional and molecular imaging in cancer drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Overview: Translating Hsp90 Biology into Hsp90 Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

Genetic interactions between Hsp90 and the Cdc2 mitotic machineryin the fission yeast Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.529

21 January 2018

Identifiers

DOI

10.2217/14796694.1.4.529

1 reference

14 August 2017

1 reference

PubMed ID

16556029