Safety assessment of intradiscal gene therapy II: effect of dosing and vector choice (Q36435499)

14 August 2017

Safety assessment of intradiscal gene therapy II: effect of dosing and vector choice (English)

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14 August 2017

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Eric A Levicoff

1

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14 August 2017

Joseph S Kim

2

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14 August 2017

Satoshi Sobajima

3

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14 August 2017

Corey J Wallach

4

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14 August 2017

James W Larson

5

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14 August 2017

Paul D Robbins

6

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14 August 2017

Xiao Xiao

7

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14 August 2017

Li Juan

8

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14 August 2017

Gianluca Vadala

9

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14 August 2017

Lars G Gilbertson

10

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14 August 2017

James D Kang

11

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14 August 2017

language of work or name

English

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publication date

1 June 2008

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14 August 2017

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14 August 2017

33

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14

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14 August 2017

1509-16; discussion 1517

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Potential use of Sox9 gene therapy for intervertebral degenerative disc disease

14 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Preclinical evaluation of gene transfer products: safety and immunological aspects

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Adeno-associated virus-based vectors in gene therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Adeno-associated viral vectors as gene delivery vehicles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Advances in adenoviral vectors: from genetic engineering to their biology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Aging and Degeneration of the Human Intervertebral Disc

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

A new technique for the assay of infectivity of human adenovirus 5 DNA

30 September 2017

1 reference

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Lumbar discography. Its value in diagnosis and treatment of lumbar disc lesions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Inducible nonviral gene expression in the treatment of osteochondral defects.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Immune responses to AAV in a phase I study for Canavan disease

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Safety assessment of intradiscal gene transfer: a pilot study

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

ISSLS prize winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Gene Transfer of the Catabolic Inhibitor TIMP-1 Increases Measured Proteoglycans in Cells from Degenerated Human Intervertebral Discs

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Sports medicine approach to low back pain

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Immediate and long-term safety of recombinant adeno-associated virus injection into the nonhuman primate muscle

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Gene delivery to in situ veins: differential effects of adenovirus and adeno-associated viral vectors

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Gene therapy death prompts review of adenovirus vector

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510668

Intraneural colchicine inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene delivery

21 September 2018

1 reference

12 December 2020

Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2

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12 December 2020

Immunohistochemical study of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 human intervertebral discs

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12 December 2020

Adenovirus-mediated gene transfer to nucleus pulposus cells. Implications for the treatment of intervertebral disc degeneration

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12 December 2020

Osteoarthrosis of the facet joints resulting from anular rim lesions in sheep lumbar discs

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12 December 2020

The adeno associated viral vector as a strategy for intradiscal gene transfer in immune competent and pre-exposed rabbits

1 reference

12 December 2020

10.1097/BRS.0B013E318178866C

Identifiers

DOI

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14 August 2017

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14 August 2017

PubMed publication ID

18520636

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