DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia (Q36442530)

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25 February 2020

title

DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia (English)

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25 February 2020

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acute myeloid leukemia

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11

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25 February 2020

Humberto J Ferreira

1

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25 February 2020

Holger Heyn

2

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25 February 2020

Anna Martínez-Cardús

7

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25 February 2020

Sebastian Moran

9

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25 February 2020

author name string

M Vizoso

3

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25 February 2020

C Moutinho

4

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25 February 2020

E Vidal

5

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25 February 2020

A Gomez

6

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25 February 2020

L Simó-Riudalbas

8

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E Jost

10

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25 February 2020

language of work or name

English

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publication date

5 October 2015

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25 February 2020

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25 February 2020

volume

35

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25 February 2020

issue

23

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25 February 2020

page(s)

3079-3082

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Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes

25 February 2020

cites work

1 reference

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DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies

30 September 2017

1 reference

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The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

30 September 2017

1 reference

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

30 September 2017

1 reference

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Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex

30 September 2017

1 reference

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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

30 September 2017

1 reference

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DNMT3A Mutations in Acute Myeloid Leukemia

30 September 2017

1 reference

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Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

30 September 2017

1 reference

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New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes

30 September 2017

1 reference

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Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

30 September 2017

1 reference

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Landmark analysis of DNMT3A mutations in hematological malignancies

30 September 2017

1 reference

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Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

21 September 2018

1 reference

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Low frequency of DNMT3A mutations in pediatric AML and the identification of the OCI-AML3 cell line as an in vitro model

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2015.359

Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2015.359

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2015.359

31 March 2020

Identifiers

DOI

10.1038/ONC.2015.359

1 reference

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25 February 2020

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25 February 2020

PubMed publication ID

26434589

1 reference