Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity (Q36447926)

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English	Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

14 August 2017

Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

1 reference

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Robert S. Negrin

6

object named as

Robert S Negrin

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Europe PubMed Central

PMC publication ID

14 August 2017

author name string

Robert Zeiser

1

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Europe PubMed Central

PMC publication ID

14 August 2017

Sawsan Youssef

2

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Europe PubMed Central

PMC publication ID

14 August 2017

Jeanette Baker

3

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Europe PubMed Central

PMC publication ID

14 August 2017

Neeraja Kambham

4

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Europe PubMed Central

PMC publication ID

14 August 2017

Lawrence Steinman

5

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Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

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publication date

7 September 2007

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Europe PubMed Central

PMC publication ID

14 August 2017

number of pages

11

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Europe PubMed Central

PMC publication ID

14 August 2017

110

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Europe PubMed Central

PMC publication ID

14 August 2017

13

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Europe PubMed Central

PMC publication ID

14 August 2017

4588-4598

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Europe PubMed Central

PMC publication ID

14 August 2017

Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level

1 reference

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Breast cancer growth prevention by statins

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1 reference

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T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription

1 reference

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Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin

1 reference

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Protein sensors for membrane sterols

1 reference

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In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets

1 reference

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Causal protein-signaling networks derived from multiparameter single-cell data

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Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial

1 reference

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HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: new implications for atherosclerosis

1 reference

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The Pathophysiology of Acute Graft-versus-Host Disease

1 reference

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Safety of HMG-CoA reductase inhibitors: focus on atorvastatin

1 reference

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Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234784

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Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

1 reference

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Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice

1 reference

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Rho GTPases and signaling networks

1 reference

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STATs and gene regulation

1 reference

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Protein prenylation: molecular mechanisms and functional consequences

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Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis

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28 June 2018

Recent advances in graft-versus-host disease (GVHD) prevention

1 reference

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28 June 2018

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

1 reference

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28 June 2018

Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234784

28 June 2018

Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234784

28 June 2018

Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production

1 reference

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Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234784

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A prospective trial to evaluate the safety and efficacy of pravastatin for the treatment of refractory chronic graft-versus-host disease

1 reference

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Oral simvastatin treatment in relapsing-remitting multiple sclerosis

1 reference

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CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234784

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A novel anti-inflammatory role for simvastatin in inflammatory arthritis

1 reference

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APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease

1 reference

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The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

1 reference

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1 reference

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Effect of pravastatin on outcomes after cardiac transplantation.

1 reference

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Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of graft versus host disease by inactivation of host antigen-presenting cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relation of an Interleukin-10 Promoter Polymorphism to Graft-versus-Host Disease and Survival after Hematopoietic-Cell Transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Graft-versus-host disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fertility and general reproduction studies in rats with the HMG-CoA reductase inhibitor, atorvastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple-dose pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an inhibitor of HMG-CoA reductase, in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High spontaneous IL-10 production in unrelated bone marrow transplant recipients is associated with fewer transplant-related complications and early deaths

1 reference

https://pubmed.ncbi.nlm.nih.gov/17827390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2007-08-106005

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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