Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets (Q35158939)

6 August 2017

title

Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets (English)

1 reference

6 August 2017

B Nikolic

1

1 reference

6 August 2017

S Lee

2

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6 August 2017

R T Bronson

3

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6 August 2017

M J Grusby

4

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6 August 2017

M Sykes

5

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6 August 2017

language of work or name

English

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publication date

1 May 2000

1 reference

Journal of Clinical Investigation

6 August 2017

published in

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6 August 2017

volume

105

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6 August 2017

issue

9

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6 August 2017

page(s)

1289-1298

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Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Gal alpha 1,3Gal-mediated graft rejection

6 August 2017

cites work

1 reference

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Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

13 July 2018

1 reference

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Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice

13 July 2018

1 reference

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A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells

13 July 2018

1 reference

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On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses

13 July 2018

1 reference

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Chemokines and T lymphocytes: more than an attraction

13 July 2018

1 reference

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Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice

13 July 2018

1 reference

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Impaired interleukin 4 signaling in T helper type 1 cells.

13 July 2018

1 reference

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T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

13 July 2018

1 reference

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CD4+ T-cell subsets in autoimmunity

13 July 2018

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Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells

13 July 2018

1 reference

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Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s

13 July 2018

1 reference

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Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells

13 July 2018

1 reference

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Recent advances in graft-versus-host disease (GVHD) prevention

13 July 2018

1 reference

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Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease

13 July 2018

1 reference

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T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice

13 July 2018

1 reference

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Functional diversity of helper T lymphocytes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

13 July 2018

1 reference

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Essential role of Stat6 in IL-4 signalling

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantation. The IgE allotype is an important marker of graft-versus-host disease.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Th1 and Th2 subsets: paradigms lost?

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

T cell depletion in bone marrow transplantation for leukemia: current results and future directions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Interleukin 2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

The mechanism of IL-2-mediated protection against GVHD in mice. II. Protection occurs independently of NK/LAK cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Cytokine dysregulation and acute graft-versus-host disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=315439

Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation

27 September 2018

1 reference

12 December 2020

Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease

1 reference

12 December 2020

Immunoglobulin dysregulation in murine graft-vs-host disease: a hyper-IgE syndrome

1 reference

12 December 2020

Immunoglobulin E levels following allogeneic, autologous, and syngeneic bone marrow transplantation: an indirect association between hyperproduction and acute graft-v-host disease in allogeneic BMT

1 reference

12 December 2020

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement

1 reference

12 December 2020

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule

1 reference

12 December 2020

Monoclonal antibodies to mouse major histocompatibility complex antigens.

1 reference

12 December 2020

Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease

1 reference

12 December 2020

Interleukin-12 inhibits murine graft-versus-host disease

1 reference

12 December 2020

Inhibition of graft-versus-host disease by interleukin-2 treatment is associated with altered cytokine production by expanded graft-versus-host-reactive CD4+ helper cells

1 reference

12 December 2020

Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts

1 reference

12 December 2020

Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment

1 reference

12 December 2020

Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice

1 reference

12 December 2020

Effects of exogenous interleukin-10 in a murine model of graft-versus-host disease to minor histocompatibility antigens

1 reference

12 December 2020

IL-2 reduces graft-versus-host disease and preserves a graft-versus-leukemia effect by selectively inhibiting CD4+ T cell activity

1 reference

12 December 2020

Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice

1 reference

12 December 2020

Selective inhibition of CD4 graft-versus-host activity in IL-2-treated mice

1 reference

12 December 2020

Increased IgE level as a marker of host-versus-graft disease: inhibition of this HVGD with a monoclonal antibody to IL-4

1 reference

12 December 2020

Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease

1 reference

12 December 2020

CD30 cell expression and abnormal soluble CD30 serum accumulation in Omenn's syndrome: evidence for a T helper 2-mediated condition

1 reference

12 December 2020

Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease

1 reference

12 December 2020

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

1 reference

12 December 2020

Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease

1 reference

12 December 2020

Interleukin-12 inhibits graft-versus-host disease through an Fas-mediated mechanism associated with alterations in donor T-cell activation and expansion

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI7894

1 reference

6 August 2017

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6 August 2017

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