Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer (Q36448676)

14 August 2017

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title

Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer (English)

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14 August 2017

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Harriet Wikman

1

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PubMed ID

16613540

14 August 2017

Eeva Kettunen

series ordinal

2

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14 August 2017

1 April 2006

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Expert Review of Anticancer Therapy

14 August 2017

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14 August 2017

6

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14 August 2017

515-530

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14 August 2017

4

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Cancer genes and the pathways they control

14 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

The E2F transcriptional network: old acquaintances with new faces

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Regulators of G1 cyclin-dependent kinases and cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cyclins and cdks in development and cancer: a perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cell cycle regulation and its aberrations in human lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Mutation and cancer: statistical study of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Role of Rb family in the epigenetic definition of chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

The retinoblastoma tumour suppressor in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Gankyrin: an intriguing name for a novel regulator of p53 and RB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Expression of p53, pRB, and p16 in lung tumours: a validation study on tissue microarrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Divergent cyclin B1 expression and Rb/p16/cyclin D1 pathway aberrations among pulmonary neuroendocrine tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Reduced transcription of the RB2/p130 gene in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Tumor-specific exon 1 mutations could be the 'hit event' predisposing Rb2/p130 gene to epigenetic silencing in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Mouse development and cell proliferation in the absence of D-cyclins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Minireview: Cyclin D1: normal and abnormal functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Abnormal expression of CCND1 and RB1 in resection margin epithelia of lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cyclin D1 and human neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Gene expression profiling of malignant mesothelioma cell lines: cDNA array study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Immunohistochemistry of cyclin D3 in pulmonary carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cyclin D1 overexpression in bronchial epithelia of patients with lung cancer is associated with smoking and predicts survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Telomere shortening and telomerase reverse transcriptase expression in preinvasive bronchial lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Overexpression of cdk4/cyclin D1, a possible mediator of apoptosis and an indicator of prognosis in human primary lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Invasive melanoma in Cdk4-targeted mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Enhanced malignant tumorigenesis in Cdk4 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Identification of CDK4 as a target of c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Evidence for a cancer-specific switch at the CDK4 promoter with loss of control by both USF and c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cyclin-dependent kinases regulate the antiproliferative function of Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Clinical implications of cyclins, cyclin-dependent kinases, RB and E2F1 in squamous-cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Relevance of proliferative and pro-apoptotic factors in non-small-cell lung cancer for patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Role of cdk4, p16INK4, and Rb expression in the prognosis of bronchioloalveolar carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

CDK4is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Absence of R24C Mutation of the CDK4 Gene in Leukemias and Solid Tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Putative gene loci associated with carcinogenesis and metastasis of endocervical adenocarcinomas of uterus determined by conventional and array-based CGH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Chromosomal imbalances in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cell cycle in mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Disruption of the RB pathway and cell-proliferative activity in non-small-cell lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary non-small cell lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

New developments in melanoma genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Gene-promoter hypermethylation as a biomarker in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Aberrant p16 promoter methylation in smokers and former smokers with nonsmall cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Expression of p15 and p15.5 products in neuroendocrine lung tumours: relationship with p15(INK4b) methylation status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Alterations of cell cycle regulators are less frequent in advanced non-small cell lung cancer than in resectable tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cyclin D1, p16 and retinoblastoma gene product expression as a predictor for prognosis in non-small cell lung cancer at stages I and II

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Cell cycle molecular targets in novel anticancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

To cycle or not to cycle: a critical decision in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Small-molecule cyclin-dependent kinase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Methylation profiling of archived non-small cell lung cancer: a promising prognostic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Aberrant promoter methylation of p16(INK4a), RARB2 and SEMA3B in bronchial aspirates from patients with suspected lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Can aberrant promoter hypermethylation of CpG islands predict the clinical outcome of non-small cell lung cancer after curative resection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Frequent p16INK4a promoter hypermethylation in human papillomavirus-infected female lung cancer in Taiwan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

K-ras and p16(INK4A)alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Hypermethylation of p16INK4a in Chinese lung cancer patients: biological and clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Anthracotic index and DNA methylation status of sputum contents can be used for identifying the population at risk of lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.4.515

21 January 2018

Identifiers

DOI

10.1586/14737140.6.4.515

1 reference

14 August 2017

1 reference

PubMed ID

16613540