AMP-activated protein kinase--development of the energy sensor concept. (Q36462587)

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20 January 2020

review article

1 reference

title

AMP-activated protein kinase--development of the energy sensor concept (English)

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20 January 2020

1

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20 January 2020

John W Scott

series ordinal

3

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20 January 2020

author name string

Simon A Hawley

series ordinal

2

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20 January 2020

language of work or name

English

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publication date

27 April 2006

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20 January 2020

published in

Journal of Physiology

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20 January 2020

volume

574

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20 January 2020

issue

Pt 1

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20 January 2020

page(s)

7-15

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AMPK: a key sensor of fuel and energy status in skeletal muscle

20 January 2020

cites work

1 reference

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Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing

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Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 September 2018

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Structural basis for glycogen recognition by AMP-activated protein kinase

21 September 2018

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Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?

21 September 2018

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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

21 September 2018

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Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

21 September 2018

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

21 September 2018

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The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

21 September 2018

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Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.

21 September 2018

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Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

21 September 2018

1 reference

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 September 2018

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Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells.

21 September 2018

1 reference

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Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

21 September 2018

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The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

21 September 2018

1 reference

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Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

21 September 2018

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AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

21 September 2018

1 reference

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21 September 2018

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Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

21 September 2018

1 reference

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 September 2018

1 reference

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

21 September 2018

1 reference

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AMP-activated protein kinase plays a role in the control of food intake

21 September 2018

1 reference

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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

21 September 2018

1 reference

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Bateman domains and adenosine derivatives form a binding contract

21 September 2018

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TSC2 mediates cellular energy response to control cell growth and survival

21 September 2018

1 reference

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 September 2018

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 September 2018

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Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex

21 September 2018

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Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

21 September 2018

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Management of cellular energy by the AMP-activated protein kinase system

21 September 2018

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AMPK beta subunit targets metabolic stress sensing to glycogen

21 September 2018

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A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.

21 September 2018

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Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

21 September 2018

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Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells

21 September 2018

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Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

21 September 2018

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AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

21 September 2018

1 reference

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Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells

21 September 2018

1 reference

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5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle

21 September 2018

1 reference

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 September 2018

1 reference

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Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

21 September 2018

1 reference

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Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

21 September 2018

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Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles.

21 September 2018

1 reference

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The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase

21 September 2018

1 reference

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Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)

21 September 2018

1 reference

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The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

21 September 2018

1 reference

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

21 September 2018

1 reference

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Role of AMP-activated protein kinase in mechanism of metformin action

21 September 2018

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Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line

21 September 2018

1 reference

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A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

21 September 2018

1 reference

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Cellular mechanism of oxygen sensing

21 September 2018

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Very high risk of cancer in familial Peutz-Jeghers syndrome

21 September 2018

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Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

21 September 2018

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beta-subunits of Snf1 kinase are required for kinase function and substrate definition

21 September 2018

1 reference

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Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase

21 September 2018

1 reference

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Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

21 September 2018

1 reference

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

21 September 2018

1 reference

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

21 September 2018

1 reference

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Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle

21 September 2018

1 reference

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5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle

21 September 2018

1 reference

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AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.

21 September 2018

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Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase

21 September 2018

1 reference

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Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta

21 September 2018

1 reference

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AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

21 September 2018

1 reference

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AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

21 September 2018

1 reference

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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 September 2018

1 reference

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

21 September 2018

1 reference

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The structure of a domain common to archaebacteria and the homocystinuria disease protein

21 September 2018

1 reference

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Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

21 September 2018

1 reference

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Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.

21 September 2018

1 reference

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Carotid body chemoreceptors: from natural stimuli to sensory discharges

21 September 2018

1 reference

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Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo.

21 September 2018

1 reference

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5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

21 September 2018

1 reference

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Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5'-monophosphate.

21 September 2018

1 reference

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Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase

21 September 2018

1 reference

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Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1817788

Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1817788

Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans

21 September 2018

1 reference

12 December 2020

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase

1 reference

12 December 2020

Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase

1 reference

12 December 2020

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

1 reference

12 December 2020

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

1 reference

12 December 2020

High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase

1 reference

12 December 2020

Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio

1 reference

12 December 2020

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

1 reference

12 December 2020

Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation

1 reference

12 December 2020

Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosol

1 reference

12 December 2020

10.1113/JPHYSIOL.2006.108944

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16644800%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

0 references

1 reference