Targeting glycogen synthase kinase-3 as an approach to develop novel mood-stabilising medications (Q36481051)

14 August 2017

1 reference

title

Targeting glycogen synthase kinase-3 as an approach to develop novel mood-stabilising medications (English)

1 reference

14 August 2017

Todd D Gould

1

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PubMed ID

16706678

14 August 2017

language of work or name

English

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publication date

1 June 2006

1 reference

Expert Opinion on Therapeutic Targets

14 August 2017

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14 August 2017

10

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14 August 2017

377-392

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14 August 2017

3

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Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication

14 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Mood disorders in the medically ill: scientific review and recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Burden of disease--implications for future research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Genetic epidemiology of major depression: review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Heritability estimates for psychotic disorders: the Maudsley twin psychosis series

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance--a population-based twin study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Neuroplasticity and cellular resilience in mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium augmentation therapy in refractory depression-update 2002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

21 January 2018

Lithium treatment at 52.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Placebo response in studies of major depression: variable, substantial, and growing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Competition between lithium and magnesium ions for the G-protein transducin in the guanosine 5'-diphosphate bound conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Effect of Li+ upon the Mg2+-dependent activation of recombinant Gialpha1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Neural and developmental actions of lithium: a unifying hypothesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Inositol phosphate biochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Reduced Brain Inositol in Lithium-treated Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

A common mechanism of action for three mood-stabilizing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

A molecular mechanism for the effect of lithium on development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Phospholipase C-independent Activation of Glycogen Synthase Kinase-3β and C-terminal Src Kinase by Gαq

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

GSK3 takes centre stage more than 20 years after its discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Signaling by insulin-like growth factor 1 in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

The Wnt signaling pathway in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

The Frizzled family: receptors for multiple signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium inhibits glycogen synthase kinase-3 by competition for magnesium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium and valproic acid: parallels and contrasts in diverse signaling contexts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium-mediated phosphorylation of glycogen synthase kinase-3beta involves PI3 kinase-dependent activation of protein kinase C-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Valproate in the treatment of acute mania. A placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Biphasic changes in the Ser-9 phosphorylation of glycogen synthase kinase-3beta after electroconvulsive shock in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Activation of protein kinase B (Akt) signaling after electroconvulsive shock in the rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

The effects of clozapine on the GSK-3-mediated signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

The effects of antipsychotics on beta-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

The role of estrogen in mood disorders in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Endocrine factors in the etiology of postpartum depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Role of estrogen in the treatment of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Wnt/beta-catenin and estrogen signaling converge in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 beta gene and promoter in late onset Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

GSK3B polymorphisms alter transcription and splicing in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Association analysis of the glycogen synthase kinase-3beta gene in bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

No association of two common SNPs at position -1727 A/T, -50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Regular induction of hypomania by L-dopa in "bipolar" manic-depressive patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Effects of lithium carbonate on methylphenidate-induced mood, behavior, and cognitive processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Diverse psychotomimetics act through a common signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Depression: a new animal model sensitive to antidepressant treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Antidepressant-like properties of zinc in rodent forced swim test

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

The neurobiology of zinc in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Glycogen synthase kinase 3: an emerging therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

GSK3 inhibitors: development and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Cancer morbidity in psychiatric patients: influence of lithium carbonate treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Norepinephrine in depressive reactions. A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

The catecholamine hypothesis of affective disorders: a review of supporting evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Neuroprotective effects of lithium in cultured cells and animal models of diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Mood stabilizers, glycogen synthase kinase-3beta and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Rhythms and the pharmacology of lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Molecular clock genes in man and lower animals: possible implications for circadian abnormalities in depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Circadian rhythm mechanisms in affective illness and in antidepressant drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3α and β isoforms in patients with NIDDM

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Prevalence, correlates, and comorbidity of bipolar I disorder and axis I and II disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Lithium carbonate augmentation of antidepressant treatment. An effective prescription for treatment-refractory depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Typical and atypical antipsychotics in bipolar depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Effect of sodium valproate on mania. The GABA-hypothesis of affective disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Effect of the New Antiepileptic Drug Levetiracetam in an Animal Model of Mania

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.3.377

10.1517/14728222.10.3.377

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16706678