CNS gene therapy and a nexus of complexity: systems and biology at a crossroads (Q36485942)

14 August 2017

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title

CNS gene therapy and a nexus of complexity: systems and biology at a crossroads (English)

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14 August 2017

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Carolyn M Tyler

1

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PubMed ID

16719061

14 August 2017

Howard J Federoff

series ordinal

2

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14 August 2017

1 January 2006

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14 August 2017

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14 August 2017

15

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14 August 2017

3

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14 August 2017

267-273

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The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death

14 August 2017

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

SNAP-25 and syntaxin, but not synaptobrevin 2, cooperate in the regulated release of nerve growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Characterization of Nerve Growth Factor (NGF) Release from Hippocampal Neurons: Evidence for a Constitutive and an Unconventional Sodium‐dependent Regulated Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Localization of cellular storage compartments and sites of constitutive and activity-dependent release of nerve growth factor (NGF) in primary cultures of hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Molecular pathways to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Frequency of stages of Alzheimer-related lesions in different age categories

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Differential vesicular targeting and time course of synaptic secretion of the mammalian neurotrophins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Neurotrophins live or let die: does p75NTR decide?

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Choline acetyltransferase messenger RNA expression in developing and adult rat brain: regulation by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Expression of messenger RNA coding for the nerve growth factor receptor trkA in the hippocampus of the adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Gene-environment interaction in Alzheimer's disease: a potential role for cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

ProNGF: a neurotrophic or an apoptotic molecule?

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Morphological response of axotomized septal neurons to nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Cholinergic neuropathology in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

In situ hybridization detection of trkA mRNA in brain: distribution, colocalization with p75NGFR and up-regulation by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

The aging brain: morphomolecular senescence of cortical circuits

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Nerve growth factor signaling in caveolae-like domains at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Role of nerve growth factor in the expression of trkA mRNA in cultured embryonic rat basal forebrain cholinergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Cholinesterase inhibitors: a therapeutic strategy for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Neurotrophin secretory pathways and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Sortilin is essential for proNGF-induced neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Primate nucleus basalis of Meynert p75NGFR-containing cholinergic neurons are protected from retrograde degeneration by the ganglioside GM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Recent advances in the genetics of Alzheimer's disease and vascular dementia with an emphasis on gene-environment interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

NGF-induction of the expression of ChAT mRNA in PC12 cells and primary cultures of embryonic rat basal forebrain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Molecular mechanisms regulating NGF-mediated enhancement of cholinergic neuronal phenotype: c-fos trans-activation of the choline acetyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

The neurotrophin hypothesis for synaptic plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Specificity of retrograde transport of nerve growth factor (NGF) in sensory neurons: A biochemical and morphological study

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Somatic gene transfer to the adult primate central nervous system: in vitro and in vivo characterization of cells genetically modified to secrete nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

NGF deprivation of adult rat brain results in cholinergic hypofunction and selective impairments in spatial learning

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxicity in the rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

A combination of mutations enhances the neurotropism of AAV-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Illustration of dynamic changes in Alzheimer pathology: from mild cognitive impairment to terminal stage

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

Induction of cell death by endogenous nerve growth factor through its p75 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000006783982007

10.3727/000000006783982007

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16719061