Molecular pathways to neurodegeneration (Q35844771)

10 August 2017

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title

Molecular pathways to neurodegeneration (English)

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10 August 2017

Robert Schwarzenbacher

series ordinal

2

object named as

Robert Schwarzenbacher

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10 August 2017

Ella Bossy-Wetzel

1

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PubMed ID

15272266

10 August 2017

Stuart A Lipton

series ordinal

3

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PubMed ID

15272266

10 August 2017

language of work or name

English

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publication date

1 July 2004

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10 August 2017

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10 August 2017

10 Suppl

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10 August 2017

S2-9

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https://scigraph.springernature.com/pub.10.1038/nm1067

10 August 2017

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cites work

Folding proteins in fatal ways

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7 January 2021

Amyloid, the presenilins and Alzheimer's disease

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7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

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7 January 2021

Tau pathology: a marker of neurodegenerative disorders.

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7 January 2021

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

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7 January 2021

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

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7 January 2021

Solution structure of methionine-oxidized amyloid beta-peptide (1-40). Does oxidation affect conformational switching?

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7 January 2021

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

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7 January 2021

The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases

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7 January 2021

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

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7 January 2021

Reconstitution of gamma-secretase activity

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7 January 2021

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

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7 January 2021

Genetics of Alzheimer's disease

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

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7 January 2021

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

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7 January 2021

Risk of Alzheimer's disease and duration of NSAID use.

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7 January 2021

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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7 January 2021

Turning down, but not off.

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7 January 2021

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

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7 January 2021

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

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7 January 2021

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport

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7 January 2021

Alzheimer's disease is a synaptic failure

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7 January 2021

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

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7 January 2021

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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7 January 2021

Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits

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7 January 2021

Rapid induction of Alzheimer A beta amyloid formation by zinc.

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7 January 2021

Copper, iron and zinc in Alzheimer's disease senile plaques.

1 reference

7 January 2021

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

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7 January 2021

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

1 reference

7 January 2021

Copper, Zinc, and the Metallobiology of Alzheimer Disease

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7 January 2021

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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7 January 2021

Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels

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7 January 2021

Metal complexing agents as therapies for Alzheimer's disease

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7 January 2021

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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7 January 2021

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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7 January 2021

Mitochondrial abnormalities in Alzheimer's disease.

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7 January 2021

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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7 January 2021

Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons

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7 January 2021

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

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7 January 2021

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

1 reference

7 January 2021

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

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7 January 2021

Genes and parkinsonism

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7 January 2021

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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7 January 2021

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

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7 January 2021

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7 January 2021

Increased susceptibility to MPTP toxicity in middle-aged rhesus monkeys

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7 January 2021

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

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7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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7 January 2021

Caught in the act: alpha-synuclein is the culprit in Parkinson's disease

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7 January 2021

Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease

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7 January 2021

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

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7 January 2021

Parkin's substrates and the pathways leading to neuronal damage

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7 January 2021

RING finger 1 mutations in Parkin produce altered localization of the protein

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7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

7 January 2021

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

1 reference

7 January 2021

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

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7 January 2021

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

1 reference

7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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7 January 2021

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

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7 January 2021

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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7 January 2021

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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7 January 2021

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

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7 January 2021

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

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7 January 2021

Pathways to Parkinsonism

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7 January 2021

DJ-1 has a role in antioxidative stress to prevent cell death

1 reference

7 January 2021

The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease

1 reference

7 January 2021

The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

1 reference

7 January 2021

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

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7 January 2021

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

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7 January 2021

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

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7 January 2021

Huntingtin in health and disease

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7 January 2021

The hunt for huntingtin function: interaction partners tell many different stories

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7 January 2021

Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE).

1 reference

7 January 2021

HEAT repeats in the Huntington's disease protein

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7 January 2021

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

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7 January 2021

Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

1 reference

7 January 2021

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

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7 January 2021

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

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7 January 2021

A huntingtin-associated protein enriched in brain with implications for pathology

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7 January 2021

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

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7 January 2021

Polyglutamines stop traffic: axonal transport as a common target in neurodegenerative diseases

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7 January 2021

Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

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7 January 2021

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

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7 January 2021

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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7 January 2021

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

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7 January 2021

CRE-mediated transcription is increased in Huntington's disease transgenic mice.

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7 January 2021

Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis

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7 January 2021

Modeling Huntington's disease in cells, flies, and mice

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7 January 2021

Lessons from animal models of Huntington's disease

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7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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7 January 2021

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

1 reference

7 January 2021

Amyloid diseases: abnormal protein aggregation in neurodegeneration

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7 January 2021

A possible therapeutic target for Lou Gehrig's disease

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7 January 2021

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

1 reference

7 January 2021

Glutamate receptors: RNA editing and death of motor neurons

1 reference

7 January 2021

Sporadic ALS: blame it on the editor

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1067

1 reference

10 August 2017

1 reference

PubMed ID

15272266