Thematic review series: patient-oriented research. What we have learned about VLDL and LDL metabolism from human kinetics studies (Q36487064)

14 August 2017

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title

Thematic review series: patient-oriented research. What we have learned about VLDL and LDL metabolism from human kinetics studies (English)

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14 August 2017

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Klaus G Parhofer

1

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PubMed ID

16720894

14 August 2017

P Hugh R Barrett

series ordinal

2

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14 August 2017

23 May 2006

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Journal of Lipid Research

14 August 2017

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14 August 2017

47

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14 August 2017

1620-1630

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14 August 2017

8

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Apolipoprotein B metabolism: tracer kinetics, models, and metabolic studies

14 August 2017

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Methods for measuring lipid metabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

New model for kinetic studies of HDL metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Regulation of the production and catabolism of plasma low density lipoproteins in hypertriglyceridemic subjects. Effect of weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Kinetics of very-low-density lipoprotein apolipoprotein B-100 in normolipidemic subjects: pooled analysis of stable-isotope studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Apolipoprotein B metabolism in humans: studies with stable isotope-labeled amino acid precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effects of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Suppression by diets rich in fish oil of very low density lipoprotein production in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effect of simvastatin on receptor-dependent low density lipoprotein catabolism in normocholesterolemic human volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Metabolic studies in familial hypercholesterolemia. Evidence for a gene-dosage effect in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Low-density lipoprotein receptor structure and folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Homozygous familial defective apolipoprotein B-100. Enhanced removal of apolipoprotein E-containing VLDLs and decreased production of LDLs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

The role of the LDL receptor in apolipoprotein B secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

In vivo metabolism of LDL subfractions in patients with heterozygous FH on statin therapy: rebound analysis of LDL subfractions after LDL apheresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Thematic review series: patient-oriented research. Design and analysis of lipoprotein tracer kinetics studies in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Recent studies of lipoprotein kinetics in the metabolic syndrome and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in NIDDM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Chylomicron remnant metabolism studied with a new breath test in postmenopausal women with and without type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Fat compartments and apolipoprotein B-100 kinetics in overweight-obese men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Overproduction of large VLDL particles is driven by increased liver fat content in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Adipocytokines and VLDL metabolism: independent regulatory effects of adiponectin, insulin resistance, and fat compartments on VLDL apolipoprotein B-100 kinetics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

The many faces of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

HDL metabolism in hypertriglyceridemic states: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Kinetic studies of lipoprotein metabolism in the metabolic syndrome including effects of nutritional interventions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effects of atorvastatin versus fenofibrate on apoB-100 and apoA-I kinetics in mixed hyperlipidemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Influence of atorvastatin and simvastatin on apolipoprotein B metabolism in moderate combined hyperlipidemic subjects with low VLDL and LDL fractional clearance rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effect of atorvastatin on apolipoprotein B100 containing lipoprotein metabolism in type-2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Treatment with high-dose simvastatin reduces secretion of apolipoprotein B-lipoproteins in patients with diabetic dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

REVIEW: Efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Differential regulation of lipoprotein kinetics by atorvastatin and fenofibrate in subjects with the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Factorial study of the effects of atorvastatin and fish oil on dyslipidaemia in visceral obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Atorvastatin improves postprandial lipoprotein metabolism in normolipidemlic subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effect of pioglitazone on lipids in well controlled patients with diabetes mellitus type 2 -- results of a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in patients with familial dysbetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Metabolism of chylomicrons in subjects with dysbetalipoproteinaemia (type III hyperlipoproteinaemia).

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effects of fenofibrate on apolipoprotein kinetics in patients with coexisting dysbetalipoproteinemia and heterozygous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Familial hypobetalipoproteinemia: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Familial hypobetalipoproteinemia: genetics and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Lipoproteins containing the truncated apolipoprotein, Apo B-89, are cleared from human plasma more rapidly than Apo B-100-containing lipoproteins in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Synthesis and secretion of hepatic apolipoprotein B-containing lipoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Apolipoprotein B-100 kinetics in visceral obesity: associations with plasma apolipoprotein C-III concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Molecular and metabolic basis for the metabolic disorder normotriglyceridemic abetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Spillover of Dietary Fatty Acids and Use of Serum Nonesterified Fatty Acids for the Synthesis of VLDL-Triacylglycerol Under Two Different Feeding Regimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Human apolipoprotein (Apo) B-48 and ApoB-100 kinetics with stable isotopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Increased hepatic secretion of very-low-density-lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: a stable isotope study

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Influence of combined therapy with mevinolin and interruption of bile-acid reabsorption on low density lipoproteins in heterozygous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Lovastatin therapy in receptor-negative homozygous familial hypercholesterolemia: Lack of effect on low-density lipoprotein concentrations or turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Simvastatin decreases the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: pathophysiological and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Lifibrol enhances the low density lipoprotein apolipoprotein B-100 turnover in patients with hypercholesterolemia and mixed hyperlipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Low-density lipoprotein-apolipoprotein B metabolism following apheresis: simulation studies of mass changes and tracer kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 studied with a stable isotope technique in men with visceral obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Plasma apolipoprotein B metabolism in familial type III dysbetalipoproteinaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Homozygous familial hypobetalipoproteinemia. Increased LDL catabolism in hypobetalipoproteinemia due to a truncated apolipoprotein B species, apo B-87Padova

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

Apoprotein B-100 production is decreased in subjects heterozygous for truncations of apoprotein B

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R600013-JLR200

10.1194/JLR.R600013-JLR200

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16720894